ArticleDrug safety2010
Preventability of drug-related harms - part II: proposed criteria, based on frameworks that classify adverse drug reactions.
Article in Drug safety, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Methods for assessing the preventability of adverse drug events: a systematic review.Drug safety · 2012Pooled it
- Preventability of drug-related harms - part I: a systematic review.Drug safety · 2010Pooled it
- Article
- Antiviral Use in Mild-to-Moderate SARS-CoV-2 Infections during the Omicron Wave in Geriatric Patients.Viruses · 2024Article
- What I have learnt from helping thousands of people taper off antidepressants and other psychotropic medications.Therapeutic advances in psychopharmacology · 2021Review
- Defining and classifying terminology for medication harm: a call for consensus.European journal of clinical pharmacology · 2019Review
- Characterization of adverse drug reactions causing admission to an intensive care unit.British journal of clinical pharmacology · 2017Article
- Quality of pharmacotherapy in old age: focus on lists of Potentially Inappropriate Medications (PIMs) : Consensus statements from the European Science Foundation exploratory workshop.European journal of clinical pharmacology · 2016Article
- The law of mass action and the pharmacological concentration-effect curve: resolving the paradox of apparently non-dose-related adverse drug reactions.British journal of clinical pharmacology · 2016Review
- Article
- Modelling drug-related morbidity in Sweden using an expert panel of physicians.European journal of clinical pharmacology · 2012Article
- Adverse drug reactions.British journal of clinical pharmacology · 2012Article
- Prevention and pharmacovigilance: what should we do, what can we do?Drug safety · 2012Article
- Preventable and non-preventable adverse drug events in hospitalized patients: a prospective chart review in the Netherlands.Drug safety · 2011Article
- Comprehensive evaluations of the adverse effects of drugs: importance of appropriate study selection and data sources.Therapeutic advances in drug safety · 2011Review
- Detecting medication errors in the New Zealand pharmacovigilance database: a retrospective analysis.Drug safety · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background'Preventability' is a crucial concept in the literature on adverse drug effects. However, a systematic review of the definitions of preventability of adverse drug effects has suggested that none fits all circumstances. Furthermore, when the reliability of these definitions has been examined they have been found to be imperfect.
objectiveTo propose and outline a method for determining the theoretical preventability of an adverse drug effect, based on frameworks for classifying adverse drug reactions - the EIDOS and DoTS methods.
methodsEIDOS is based on the mechanism of action of the drug. It observes that a drug (an Extrinsic species) causes an adverse effect by interacting with an Intrinsic species that is its target when the two are Distributed together, and that the resulting pathophysiological Outcome (the adverse effect) causes the Sequela (the adverse reaction). DoTS observes that the Dose-relatedness of the adverse effect compared with the beneficial effect is relevant (determining toxic, collateral, or hypersusceptibility effects), that adverse effects have Time-courses (varying from immediate to delayed), and that there are individual Susceptibility factors. RESULTS AND DISCUSSION: We have elicited many published examples that show that each of these factors in the causation of an adverse drug effect can be adduced to assess its preventability. We have constructed a flowchart that illustrates how the processes can be logically analysed.
conclusionsThis approach suggests methods for devising prospective preventive strategies and for deciding retrospectively whether an adverse reaction in an individual should have been prevented.
Indexed as
Identifiers
20925437What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.