ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Sox17 and chordin are required for formation of Kupffer's vesicle and left-right asymmetry determination in zebrafish.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- Functional genomics analysis of developing zebrafish and human endoderm reveals highly conservedGenome research · 2026Article
- Molecular and Functional Divergence of Zebrafish Sox Paralogs Controlling Endoderm Formation and Left-Right Patterning.Genome biology and evolution · 2025Article
- Ultrastructure of the lamprey head mesoderm reveals evolution of the vertebrate head.iScience · 2023Article
- Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates.Nature genetics · 2022Article
- Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops.Frontiers in cell and developmental biology · 2022Article
- Article
- TGF-β Family Signaling in Early Vertebrate Development.Cold Spring Harbor perspectives in biology · 2018Review
- Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning.eLife · 2017Article
- Claudin5a is required for proper inflation of Kupffer's vesicle lumen and organ laterality.PloS one · 2017Article
- Role of ectonucleotide pyrophosphatase/phosphodiesterase 2 in the midline axis formation of zebrafish.Scientific reports · 2016Article
- Article
- Microtubule-associated protein 9 (Map9/Asap) is required for the early steps of zebrafish development.Cell cycle (Georgetown, Tex.) · 2014Article
- Differential roles for 3-OSTs in the regulation of cilia length and motility.Development (Cambridge, England) · 2013Article
- A unified model for left-right asymmetry? Comparison and synthesis of molecular models of embryonic laterality.Developmental biology · 2013Review
- Analysis of gene function and visualization of cilia-generated fluid flow in Kupffer's vesicle.Journal of visualized experiments : JoVE · 2013Article
- Functional knowledge transfer for high-accuracy prediction of under-studied biological processes.PLoS computational biology · 2013Article
- Wdr18 is required for Kupffer's vesicle formation and regulation of body asymmetry in zebrafish.PloS one · 2011Article
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2 authors at 2 institutions in 1 country.
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Abstract
Kupffer's vesicle (KV), a ciliated fluid-filled sphere in the zebrafish embryo with a critical role in laterality determination, is derived from a group of superficial cells in the organizer region of the gastrula named the dorsal forerunner cells (DFC). We have examined the role of the expression of sox17 and chordin (chd) in the DFC in KV formation and laterality determination. Whereas sox17 was known to be expressed in DFC, its function in these cells was not studied before. Further, expression of chd in these cells has not been reported previously. Targeted knockdown of Sox17 and Chd in DFC led to aberrant Left-Right (L-R) asymmetry establishment, as visualized by the expression of southpaw and lefty, and heart and pancreas placement in the embryo. These defects correlated with the formation of small KVs with apparently diminished cilia, consistent with the known requirement for ciliary function in the laterality organ for the establishment of L-R asymmetry.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.