ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2011
Orthostatic tolerance is difficult to predict in recurrent syncope patients.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Effects of short-term hypercaloric nutrition on orthostatic tolerance in healthy individuals: a randomized controlled crossover study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Trial
- Sex Differences in Orthostatic Tolerance Are Mainly Explained by Blood Volume and Oxygen Carrying Capacity.Critical care explorations · 2022Article
- Cardiac and Musculoskeletal Responses to the Effects of Passive and Active Tilt Test in Healthy Subjects.Arquivos brasileiros de cardiologia · 2018Article
- Early hemodynamic response to the tilt test in patients with syncope.Archives of medical science : AMS · 2014Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesWe tested the hypothesis that detailed anthropometric and hemodynamic measurements predict orthostatic tolerance in neurally mediated syncope patients. In addition, we tested whether orthostatic tolerance is related to syncope frequency in real life.
backgroundEarlier studies in patients with neurally mediated syncope suggested that orthostatic heart rate and blood pressure responses predict the tilt table responses with high sensitivity and specificity.
methodsWe analyzed data from 157 consecutive patients (n = 100 exploratory cohort, n = 57 confirmatory cohort) with recurrent syncope in whom orthostatic tolerance was quantified as the time to (pre)syncope during head-up tilt testing combined with lower body negative pressure. We measured heart rate, brachial blood pressure, cardiac stroke volume, heart rate and blood pressure variability, and spontaneous baroreflex sensitivity supine and early during head-up tilt.
resultsThe orthostatic heart rate increase showed the strongest correlation with orthostatic tolerance. The best multivariate model including age, supine diastolic blood pressure, supine blood pressure variability, as well as tilt-induced changes in diastolic blood pressure and heart rate explained no more that 40% of the variability in orthostatic tolerance. The model failed to predict orthostatic tolerance in the confirmatory cohort. Frequency or number of free-living syncopal episodes were only weakly related to orthostatic tolerance.
conclusionsIn patients with neurally mediated syncope, orthostatic tolerance in the clinical laboratory is difficult to predict with a wide range of anthropometric and cardiovascular measurements and correlates poorly with syncope occurrence in real life.
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