Evidence map›Paper›PMID 20924410›Full record

ReviewNature reviews. Rheumatology2010

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis.

Jérémie Sellam, Francis Berenbaum

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 743 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
743citing papers in PubMed, 3 pooled it
30.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03664466 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Astaxanthin Effects on Osteoarthritis Associated Pain and Inflammatory Indicators

TypeinterventionalSponsorSaint Luke's Health SystemRan2021 to 2022Enrolled0ConditionsOsteoarthritis, KneeArmsastaxanthin, Placebo
NCT04303026 phase3unknown statusnot on this mapstarted 2020, after this paper: background citation

A Randomized Placebo Controlled Trial Testing The Effect of Zoledronic Acid on Hip Osteoarthritis

TypeinterventionalSponsorVestre Viken Hospital TrustRan2020 to 2024Enrolled70ConditionsOsteoarthritis, HipArmsZoledronic Acid, Saline 0.9%
NCT06082271 nacompletednot on this mapstarted 2021, after this paper: background citation

Comparative, Randomized Study on the Anti-inflammatory and Regenerative Efficacy of a New Medical Device (DM) Based on Hydrolyzed Collagen Peptides in Patients With Femoro-acetabular Impingement Undergoing Hip Arthroscopy

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2021 to 2023Enrolled25ConditionsFemoroacetabular Impingement, Hip Arthroscopy, Hip Osteoarthritis, Hydrolyzed Collagen PeptidesArmsClass III medical Hydrolyzed Collagen Peptides PEP-52 (Peptys), Cortisone
3 · Its place in the literature

Who cites it

743 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,464 citations in OpenAlex.

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  9. Emerging therapies for knee osteoarthritis.Nature reviews. Rheumatology · 2026
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683 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jérémie SellamPierre & Marie Curie University, Department of Rheumatology, AP-HP Saint-Antoine Hospital, 184 rue du Faubourg Saint-Antoine, Paris 75012, France.
Francis Berenbaum
Sorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms such as joint swelling, synovitis and inflammatory pain. The gold-standard method for detecting synovitis is histological analysis of samples obtained by biopsy, but the noninvasive imaging techniques MRI and ultrasonography might also perform well. The inflammation of the synovial membrane that occurs in both the early and late phases of OA is associated with alterations in the adjacent cartilage that are similar to those seen in rheumatoid arthritis. Catabolic and proinflammatory mediators such as cytokines, nitric oxide, prostaglandin E(2) and neuropeptides are produced by the inflamed synovium and alter the balance of cartilage matrix degradation and repair, leading to excess production of the proteolytic enzymes responsible for cartilage breakdown. Cartilage alteration in turn amplifies synovial inflammation, creating a vicious circle. As synovitis is associated with clinical symptoms and also reflects joint degradation in OA, synovium-targeted therapy could help alleviate the symptoms of the disease and perhaps also prevent structural progression.

Indexed as

CartilageDisease ProgressionHumansInflammationMagnetic Resonance ImagingOsteoarthritisSynovitisUltrasonography, Doppler

Identifiers

PMID20924410
OpenAlexW2017869529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.