Evidence map›Paper›PMID 20924403›Full record

ArticleNature structural & molecular biology2010

One motor driving two translocases.

Smita S Patel

Abstract readComment
PubMed Publisher
In one paragraph

Article in Nature structural & molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Smita S PatelDepartment of Biochemistry, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.
Johnson University · US

Funding

MECHANISTIC STUDIES OF HEXAMERIC HELICASESR01GM055310 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI PATEL, SMITA S · 1997 to 2015
$4.6M
NIGMS NIH HHS R01 GM055310
6 · The paper itself

Abstract

In this issue, Wu et al. show that the RecBC helicase, which is involved in repairing double-strand DNA breaks,uses one ATPase motor to drive two translocases along opposite strands of DNA—much as an all-wheel drive engine controls movement of both front and back wheels. This mechanism may allow RecBC to load onto blunt-end DNA more efficiently and to move through obstacles such as gaps and DNA damage.

Indexed as

Adenosine TriphosphateDNA, BacterialDNA Breaks, Double-StrandedDNA HelicasesDNA RepairEscherichia coliEscherichia coli ProteinsExodeoxyribonuclease VMolecular Motor ProteinsMultienzyme ComplexesProtein BindingProtein SubunitsStructure-Activity RelationshipAdenosine TriphosphateDNA, BacterialDNA HelicasesEscherichia coli ProteinsExodeoxyribonuclease Vexodeoxyribonuclease V, E coliMolecular Motor ProteinsMultienzyme ComplexesProtein Subunits

Identifiers

PMID20924403
OpenAlexW2024333863

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.