ArticleBritish journal of cancer2010
Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate.
Article in British journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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83 citing papers in PubMed.
- Early prediction of therapy responses and outcomes in breast cancer patients using quantitative ultrasound spectral texture.Oncotarget · 2014Trial
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- Assessment of the sensitivity ofNMR in biomedicine · 2023Article
- A Simulation of the Effects of Diffusion on Hyperpolarized [1-IEEE transactions on bio-medical engineering · 2023Article
- Hyperpolarized Carbon-13 MRI in Breast Cancer.Diagnostics (Basel, Switzerland) · 2023Review
- Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarizedScientific reports · 2023Article
- Application and development of Deuterium Metabolic Imaging in tumor glucose metabolism: visualization of different metabolic pathways.Frontiers in oncology · 2023Review
- Imaging Glioblastoma Response to Radiotherapy Using 2H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism.Cancer research · 2022Article
- A Field-Independent Method for the Rapid Generation of Hyperpolarized [1-Angewandte Chemie (International ed. in English) · 2022Article
- [HyperpolarizedRadiologie (Heidelberg, Germany) · 2022Review
- Advancing homogeneous catalysis for parahydrogen-derived hyperpolarisation and its NMR applications.Chemical science · 2022Review
- Conversion of Hyperpolarized [1-Cancers · 2022Article
- Direct Production of a Hyperpolarized Metabolite on a Microfluidic Chip.Analytical chemistry · 2022Article
- HyperpolarizedAntioxidants & redox signaling · 2022Review
- Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients.Cancer research · 2021Article
23 more citing papers are in PubMed but not listed here.
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Abstract
backgroundThe recent introduction of a dynamic nuclear polarisation technique has permitted noninvasive imaging of tumour cell metabolism in vivo following intravenous administration of (13)C-labelled cell substrates.
methodsChanges in hyperpolarised [1-(13)C]pyruvate and [1,4-(13)C(2)]fumarate metabolism were evaluated in both MDA-MB-231 cells and in implanted MDA-MB-231 tumours following doxorubicin treatment.
resultsTreatment of MDA-MB-231 cells resulted in the induction of apoptosis, which was accompanied by a decrease in hyperpolarised (13)C label flux between [1-(13)C]pyruvate and lactate, which was correlated with a decrease in the cellular NAD(H) coenzyme pool. There was also an increase in the rate of fumarate conversion to malate, which accompanied the onset of cellular necrosis. In vivo, the decrease in (13)C label exchange between pyruvate and lactate and the increased flux between fumarate and malate, following drug treatment, were shown to occur in the absence of any detectable change in tumour size.
conclusionWe show here that the early responses of a human breast adenocarcinoma tumour model to drug treatment can be followed by administration of both hyperpolarised [1-(13)C]pyruvate and [1,4-(13)C(2)]fumarate. These techniques could be used, therefore, in the clinic to detect the early responses of breast tumours to treatment.
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