ArticleGenome biology and evolution2010
DNA methylation and genome evolution in honeybee: gene length, expression, functional enrichment covary with the evolutionary signature of DNA methylation.
Article in Genome biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- On the presence and role of human gene-body DNA methylation.Oncotarget · 2012Pooled it
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- Evolutionary preservation of CpG dinucleotides in RAG1 may elucidate the relatively high rate of methylation-mediated mutagenesis of RAG1 transposase.Immunologic research · 2024Article
- Potential Role of DNA Methylation as a Driver of Plastic Responses to the Environment Across Cells, Organisms, and Populations.Genome biology and evolution · 2024Article
- Phenotypic dimorphism between honeybee queen and worker is regulated by complicated epigenetic modifications.iScience · 2023Article
- Comparative studies of genomic and epigenetic factors influencing transcriptional variation in two insect species.G3 (Bethesda, Md.) · 2022Article
- Lineage and Parent-of-Origin Effects in DNA Methylation of Honey Bees (Apis mellifera) Revealed by Reciprocal Crosses and Whole-Genome Bisulfite Sequencing.Genome biology and evolution · 2020Article
- Distinct epigenomic and transcriptomic modifications associated with Wolbachia-mediated asexuality.PLoS pathogens · 2020Article
- Detecting differential DNA methylation from sequencing of bisulfite converted DNA of diverse species.Briefings in bioinformatics · 2019Article
- DNA Methylation inFrontiers in immunology · 2019Article
- Characterization of bovine (Bos taurus) imprinted genes from genomic to amino acid attributes by data mining approaches.PloS one · 2019Article
- DNA methylation regulates transcriptional homeostasis of algal endosymbiosis in the coral model Aiptasia.Science advances · 2018Article
- Comparative genomics of the miniature wasp and pest control agent Trichogramma pretiosum.BMC biology · 2018Article
- Notos - a galaxy tool to analyze CpN observed expected ratios for inferring DNA methylation types.BMC bioinformatics · 2018Article
- Multiple functions of CREB-binding protein during postembryonic development: identification of target genes.BMC genomics · 2017Article
- Insights into Epigenome Evolution from Animal and Plant Methylomes.Genome biology and evolution · 2017Article
- Body-hypomethylated human genes harbor extensive intragenic transcriptional activity and are prone to cancer-associated dysregulation.Nucleic acids research · 2017Article
- Divergent DNA Methylation Provides Insights into the Evolution of Duplicate Genes in Zebrafish.G3 (Bethesda, Md.) · 2016Article
- Evolutionary Transition of Promoter and Gene Body DNA Methylation across Invertebrate-Vertebrate Boundary.Molecular biology and evolution · 2016Article
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2 authors.
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Abstract
A growing body of evidence suggests that DNA methylation is functionally divergent among different taxa. The recently discovered functional methylation system in the honeybee Apis mellifera presents an attractive invertebrate model system to study evolution and function of DNA methylation. In the honeybee, DNA methylation is mostly targeted toward transcription units (gene bodies) of a subset of genes. Here, we report an intriguing covariation of length and epigenetic status of honeybee genes. Hypermethylated and hypomethylated genes in honeybee are dramatically different in their lengths for both exons and introns. By analyzing orthologs in Drosophila melanogaster, Acyrthosiphon pisum, and Ciona intestinalis, we show genes that were short and long in the past are now preferentially situated in hyper- and hypomethylated classes respectively, in the honeybee. Moreover, we demonstrate that a subset of high-CpG genes are conspicuously longer than expected under the evolutionary relationship alone and that they are enriched in specific functional categories. We suggest that gene length evolution in the honeybee is partially driven by evolutionary forces related to regulation of gene expression, which in turn is associated with DNA methylation. However, lineage-specific patterns of gene length evolution suggest that there may exist additional forces underlying the observed interaction between DNA methylation and gene lengths in the honeybee.
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