ArticleGenetics2010
Bulk segregation mapping of mutations in closely related strains of mice.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- C3H/HeNSlc mouse with low phospholipid transfer protein expression showed dyslipidemia.Scientific reports · 2023Article
- Identification of Finely Mapped Quantitative Trait Locus and Candidate Gene Mining for the Three-Seeded Pod Trait in Soybean.Frontiers in plant science · 2021Article
- Dual-route targeted vaccine protects efficiently against botulinum neurotoxin A complex.Vaccine · 2018Article
- HCFC2 is needed for IRF1- and IRF2-dependentThe Journal of experimental medicine · 2017Article
- Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Innate immunity and the new forward genetics.Best practice & research. Clinical haematology · 2016Review
- Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies.Human molecular genetics · 2015Article
- Mapping of a quantitative trait locus controlling susceptibility to Coxsackievirus B3-induced viral hepatitis.Genes and immunity · 2015Article
- THEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis.Infection and immunity · 2015Article
- Mouse ENU Mutagenesis to Understand Immunity to Infection: Methods, Selected Examples, and Perspectives.Genes · 2014Review
- Mapping small effect mutations in Saccharomyces cerevisiae: impacts of experimental design and mutational properties.G3 (Bethesda, Md.) · 2014Article
- Ion Torrent sequencing for conducting genome-wide scans for mutation mapping analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- A deep intronic mutation in the ankyrin-1 gene causes diminished protein expression resulting in hemolytic anemia in mice.G3 (Bethesda, Md.) · 2013Article
- Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.PLoS pathogens · 2013Article
- Going forward with genetics: recent technological advances and forward genetics in mice.The American journal of pathology · 2013Review
- ENU-induced phenovariance in mice: inferences from 587 mutations.BMC research notes · 2012Article
- High throughput sequencing approaches to mutation discovery in the mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Review
- A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.Journal of virology · 2012Article
- Forward genetic approaches to understanding complex behaviors.Current topics in behavioral neurosciences · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
Phenovariance may be obscured when genetic mapping is performed using highly divergent strains, and closely similar strains are preferred if adequate marker density can be established. We sequenced the C57BL/10J mouse genome using the Applied Biosystems SOLiD platform and here describe a genome-wide panel of informative markers that permits the mapping of mutations induced on the closely related C57BL/6J background by outcrossing to C57BL/10J, and backcrossing or intercrossing. The panel consists of 127 single nucleotide polymorphisms validated by capillary sequencing: 124 spaced at ∼20-Mb intervals across the 19 autosomes, and three markers on the X chromosome. We determined the genetic relationship between four C57BL-derived substrains and used the panel to map two N-ethyl-N-nitrosourea (ENU)-induced mutations responsible for visible phenotypes in C57BL/6J mice through bulk segregation analysis. Capillary sequencing, with computation of relative chromatogram peak heights, was used to determine the proportion of alleles from each strain at each marker.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.