Evidence map›Paper›PMID 20923891›Full record

ArticleAutism : the international journal of research and practice2010

Narrowing the broader autism phenotype: a study using the Communication Checklist-Adult Version (CC-A).

Andrew J O Whitehouse, Hilary Coon, Judith Miller, Bryanna Salisbury, Dorothy V M Bishop

Abstract read
In one paragraph

Article in Autism : the international journal of research and practice, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  12. Dissociations in the neural substrates of language and social functioning in autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew J O WhitehouseTelethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, PO Box 855, West Perth, Western Australia 6872, Australia. awhitehouse@ichr.uwa.edu.au
Hilary Coon
Judith Miller
Bryanna Salisbury
Dorothy V M Bishop

Funding

Wellcome Trust 082498
6 · The paper itself

Abstract

This study investigated whether the Communication Checklist - Adult (CC-A) could identify subtypes of social and communication dysfunction in autism probands and their parents. The CC-A is divided into subscales measuring linguistic ability as well as two aspects of social communication: the Pragmatic Skills subscale assesses the level of pragmatic oddities (e.g. excessive talking), while the Social Engagement subscale picks up on those behaviours that reflect a more passive communication style (e.g. failure to engage in social interactions). CC-A data were collected for 69 autism probands, 238 parents of autism probands and 187 typical participants. The CC-A proved sensitive to the communication difficulties of autism probands and a proportion of their parents. The majority of parents who demonstrated the broader phenotype scored poorly on either the Pragmatic Skills or Social Engagement scale only. The Social Engagement scale was particularly sensitive to the difficulties of the parents, indicating that social-communicative passivity may be an important part of the broader autism phenotype. The findings provide evidence for the existence of more constrained pragmatic phenotypes in autism. Molecular genetic studies in this area may benefit from stratifying samples according to these phenotypes.

Indexed as

ChecklistCommunicationAdultAutistic DisorderExecutive FunctionFemaleHumansInterpersonal RelationsLanguageMaleMiddle AgedPhenotype

Identifiers

PMID20923891
PMCPMC3008969

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.