ArticleNucleic acids research2011
Conserved small RNAs govern replication and incompatibility of a diverse new plasmid family from marine bacteria.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Whole Genome Characterisation of Non-O1/Non-O139Microorganisms · 2026Article
- The Type III Secretion System plasmid pPHDPT3 of Photobacterium damselae subsp. piscicida is stable in Australian isolates due to conserved non-repetitive genomic architecture.FEMS microbiology letters · 2026Article
- Defence systems encoded by core genomic islands of seventh pandemicPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- The ecology and evolution of microbial immune systems: a look on the wild vibrio side.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Adaptive genomic plasticity in large-genome, broad-host-range vibrio phages.The ISME journal · 2025Article
- Replicon family of Vibrionaceae plasmids as a reservoir of antimicrobial and phage resistance genes in marine ecosystems.The ISME journal · 2025Article
- Article
- Phage-inducible chromosomal minimalist islands (PICMIs), a novel family of small marine satellites of virulent phages.Nature communications · 2024Article
- Bacterial growth in multicellular aggregates leads to the emergence of complex life cycles.Current biology : CB · 2022Article
- A Highly Unstable and Elusive Plasmid That Encodes the Type III Secretion System Is Necessary for Full Virulence in the Marine Fish PathogenInternational journal of molecular sciences · 2022Article
- Article
- Evolution of ColE1-like plasmids across γ-Proteobacteria: From bacteriocin production to antimicrobial resistance.PLoS genetics · 2021Article
- Species-specific mechanisms of cytotoxicity toward immune cells determine the successful outcome ofProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Review
- The RstAB System Impacts Virulence, Motility, Cell Morphology, Penicillin Tolerance and Production of Type II Secretion System-Dependent Factors in the Fish and Human PathogenFrontiers in microbiology · 2019Article
- Ancestral gene acquisition as the key to virulence potential in environmental Vibrio populations.The ISME journal · 2018Article
- Vibrio crassostreae, a benign oyster colonizer turned into a pathogen after plasmid acquisition.The ISME journal · 2017Article
- Article
- Populations, not clones, are the unit of vibrio pathogenesis in naturally infected oysters.The ISME journal · 2015Article
- A genomic island integrated into recA of Vibrio cholerae contains a divergent recA and provides multi-pathway protection from DNA damage.Environmental microbiology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Plasmids are autonomously replicating extrachromosomal DNA molecules that often impart key phenotypes to their bacterial hosts. Plasmids are abundant in marine bacteria, but there is scant knowledge of the mechanisms that control their replication in these hosts. Here, we identified and characterized the factors governing replication of a new family of plasmids from marine bacteria, typified by the virulence-linked plasmid pB1067 of Vibrio nigripulchritudo. Members of this family are prevalent among, yet restricted to, the Vibrionaceae. Unlike almost all plasmid families characterized to date, the ori regions of these plasmids do not encode a Rep protein to initiate DNA replication; instead, the ori regions encode two partially complementary RNAs. The smaller, termed RNA I, is ∼68-nt long and functions as a negative regulator and the key determinant of plasmid incompatibility. This Marine RNA-based (MRB) plasmid family is the first characterized family of replicons derived from marine bacteria. Only one other plasmid family (the ColE1 family) has previously been reported to rely on RNA-mediated replication initiation. However, since the sequences and structures of MRB RNA I transcripts are not related to those of ColE1 replicons, these two families of RNA-dependent replicons likely arose by convergent evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.