ArticleBiophysical journal2010
Activation or tolerance of natural killer cells is modulated by ligand quality in a nonmonotonic manner.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- A framework integrating multiscale in silico modeling and experimental data predicts CAR-NK cell cytotoxicity across target cell types.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- An Entropy-Based Approach to Model Selection with Application to Single-Cell Time-Stamped Snapshot Data.Entropy (Basel, Switzerland) · 2025Article
- Novel oral adjuvant to enhance cytotoxic memory like NK cell responses in HIV vaccine platform.NPJ vaccines · 2025Article
- An Entropy-Based Approach to Model Selection with Application to Single-Cell Time-Stamped Snapshot Data.bioRxiv : the preprint server for biology · 2025Article
- BioNetGMMFit: estimating parameters of a BioNetGen model from time-stamped snapshots of single cells.NPJ systems biology and applications · 2023Article
- McSNAC: A software to approximate first-order signaling networks from mass cytometry data.Quantitative biology (Beijing, China) · 2023Article
- Improving NK cell function in multiple myeloma with NKTR-255, a novel polymer-conjugated human IL-15.Blood advances · 2023Article
- Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation.PLoS computational biology · 2022Article
- Inhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity.eLife · 2022Article
- Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness.Science signaling · 2021Article
- An optimal control approach for enhancing natural killer cells' secretion of cytolytic molecules.APL bioengineering · 2020Article
- Enhancing network activation in natural killer cells: predictions from in silico modeling.Integrative biology : quantitative biosciences from nano to macro · 2020Article
- Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes.Frontiers in immunology · 2019Article
- Crystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors.Molecules and cells · 2018Article
- In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells.Science signaling · 2017Article
- Prenatal Allospecific NK Cell Tolerance Hinges on Instructive Allorecognition through the Activating Receptor during Development.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The limits of chemosensation vary across dimensions.Nature communications · 2015Article
- Controlling natural killer cell responses: integration of signals for activation and inhibition.Annual review of immunology · 2013Review
- Understanding natural killer cell regulation by mathematical approaches.Frontiers in immunology · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
Natural killer (NK) cells extend important immune resistance in vertebrates by lysing infected and tumor cells. A fine balance between opposing signals generated by a diverse set of stimulatory and inhibitory NK-cell receptors determines the fate of target cells interacting with the NK cells. We have developed a mathematical model involving membrane proximal initial signaling events that provides novel mechanistic insights into how activation of NK cells is modulated by the half-life of receptor-ligand interaction and ligand concentrations. We show that strong stimulatory ligands produce digital activation, whereas weaker stimulatory ligands can mediate inhibition by strengthening the signals generated by inhibitory ligands, as indicated in experiments in knockout mice. We find under certain conditions, counterintuitively, inhibitory receptors can help mediate activation instead of inhibition. Mechanistic insights gained from NK-cell signaling can facilitate understanding of complex signaling responses that occur due to cross talk between dueling signaling pathways in other cell types.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.