ArticleBMC immunology2010
Associations between SNPs in candidate immune-relevant genes and rubella antibody levels: a multigenic assessment.
Article in BMC immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Genetic polymorphisms associated with rubella virus-specific cellular immunity following MMR vaccination.Human genetics · 2014Pooled it
- Polymorphisms in Toll-like receptor genes influence antibody responses to cytomegalovirus glycoprotein B vaccine.BMC research notes · 2012Trial
- Polygenic prediction of cellular immune responses to mumps vaccine.Genes and immunity · 2025Article
- Vaccinomics: A scoping review.Vaccine · 2023Article
- Current Challenges in Vaccinology.Frontiers in immunology · 2020Review
- Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated WithFrontiers in endocrinology · 2020Article
- Factors That Influence the Immune Response to Vaccination.Clinical microbiology reviews · 2019Review
- Characterization of rubella-specific humoral immunity following two doses of MMR vaccine using proteome microarray technology.PloS one · 2017Article
- Single nucleotide polymorphisms/haplotypes associated with multiple rubella-specific immune response outcomes post-MMR immunization in healthy children.Immunogenetics · 2015Article
- Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines.Immunogenetics · 2014Article
- Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.Immunogenetics · 2014Article
- Article
- No more non-model species: the promise of next generation sequencing for comparative immunology.Developmental and comparative immunology · 2014Review
- The personal touch: strategies toward personalized vaccines and predicting immune responses to them.Expert review of vaccines · 2014Review
- Article
- Characterization of humoral and cellular immunity to rubella vaccine in four distinct cohorts.Immunologic research · 2014Article
- Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century.Seminars in immunology · 2013Review
- Genome-wide characterization of transcriptional patterns in high and low antibody responders to rubella vaccination.PloS one · 2013Article
- The genetic basis for interindividual immune response variation to measles vaccine: new understanding and new vaccine approaches.Expert review of vaccines · 2013Review
- Effects of a single nucleotide polymorphism in the chicken NK-lysin gene on antimicrobial activity and cytotoxicity of cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe mechanisms of immune response are structured within a highly complex regulatory system. Genetic associations with variation in the immune response to rubella vaccine have typically been assessed one locus at a time. We simultaneously assessed the associations between 726 SNPs tagging 84 candidate immune response genes and rubella-specific antibody levels. Blood samples were obtained from 714 school-aged children who had received two doses of MMR vaccine. Associations between rubella-specific antibody levels and 726 candidate tagSNPs were assessed both one SNP at a time and in a variety of multigenic analyses.
resultsSingle-SNP assessments identified 4 SNPs that appeared to be univariately associated with rubella antibody levels: rs2844482 (p = 0.0002) and rs2857708 (p = 0.001) in the 5'UTR of the LTA gene, rs7801617 in the 5'UTR of the IL6 gene (p = 0.0005), and rs4787947 in the 5'UTR of the IL4R gene (p = 0.002). While there was not significant evidence in favor of epistatic genetic associations among the candidate SNPs, multigenic analyses identified 29 SNPs significantly associated with rubella antibody levels when selected as a group (p = 0.017). This collection of SNPs included not only those that were significant univariately, but others that would not have been identified if only considered in isolation from the other SNPs.
conclusionsFor the first time, multigenic assessment of associations between candidate SNPs and rubella antibody levels identified a broad number of genetic associations that would not have been deemed important univariately. It is important to consider approaches like those applied here in order to better understand the full genetic complexity of response to vaccination.
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Registered trials
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