ArticleMolecular microbiology2010
Proteobactin and a yersiniabactin-related siderophore mediate iron acquisition in Proteus mirabilis.
Article in Molecular microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 76 citations in OpenAlex.
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- Insights into novel diagnostic assay development, antimicrobial resistance, and pathogenicity inApplied and environmental microbiology · 2026Article
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- Evaluation of a bivalent vaccine composed of iron scavenger receptors PMI1426 and PMI1945 againstFuture microbiology · 2025Article
- In Vitro Ferrophilic Responses ofMicroorganisms · 2025Article
- Genomic insights into a Proteus mirabilis strain inducing avian cellulitis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Proteus faecis: a potentially pathogenic bacterium isolated from the freshwater Yangtze finless porpoise.Antonie van Leeuwenhoek · 2024Article
- First report on the physicochemical and proteomic characterization ofFrontiers in microbiology · 2024Article
- Overview ofFrontiers in microbiology · 2024Review
- Organ agar serves as physiologically relevant alternative forInfection and immunity · 2023Article
- Droplet Tn-Seq identifies the primary secretion mechanism for yersiniabactin in Yersinia pestis.EMBO reports · 2023Article
- Hacking the Immune Response to Solid Tumors: Harnessing the Anti-Cancer Capacities of Oncolytic Bacteria.Pharmaceutics · 2023Review
- Evaluation ofMicroorganisms · 2023Article
- Phenotypic Assessment of Clinical Escherichia coli Isolates as an Indicator for Uropathogenic Potential.mSystems · 2022Article
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- The immune responses to differentFrontiers in immunology · 2022Review
- Relevance of iron metabolic genes in biofilm and infection in uropathogenicCurrent research in microbial sciences · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Proteus mirabilis causes complicated urinary tract infections (UTIs). While the urinary tract is an iron-limiting environment, iron acquisition remains poorly characterized for this uropathogen. Microarray analysis of P. mirabilis HI4320 cultured under iron limitation identified 45 significantly upregulated genes (P ≤ 0.05) that represent 21 putative iron-regulated systems. Two gene clusters, PMI0229-0239 and PMI2596-2605, encode putative siderophore systems. PMI0229-0239 encodes a non-ribosomal peptide synthetase-independent siderophore system for producing a novel siderophore, proteobactin. PMI2596-2605 are contained within the high-pathogenicity island, originally described in Yersinia pestis, and encodes proteins with apparent homology and organization to those involved in yersiniabactin production and uptake. Cross-feeding and biochemical analysis shows that P. mirabilis is unable to utilize or produce yersiniabactin, suggesting that this yersiniabactin-related locus is functionally distinct. Only disruption of both systems resulted in an in vitro iron-chelating defect; demonstrating production and iron-chelating activity for both siderophores. These findings clearly show that proteobactin and the yersiniabactin-related siderophore function as iron acquisition systems. Despite the activity of both siderophores, only mutants lacking the yersiniabactin-related siderophore have reduced fitness in vivo. The fitness requirement for the yersiniabactin-related siderophore during UTI shows, for the first time, the importance of siderophore production in vivo for P. mirabilis.
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