ArticleBiomacromolecules2010
Synthesis of statistical copolymers containing multiple functional peptides for nucleic Acid delivery.
Article in Biomacromolecules, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Presenting Antimicrobial Peptides on Poly(ethylene glycol): Star-Shaped vs Comb-Like Architectures.Macromolecules · 2025Article
- Thermoresponsive Polymers of Poly(2-(Polymers · 2020Article
- Dual Polymerizations: Untapped Potential for Biomaterials.Advanced healthcare materials · 2019Review
- Reducible, dibromomaleimide-linked polymers for gene delivery.Biomaterials science · 2015Article
- Peptides displayed as high density brush polymers resist proteolysis and retain bioactivity.Journal of the American Chemical Society · 2014Article
- Polymer-peptide delivery platforms: effect of oligopeptide orientation on polymer-based DNA delivery.Biomacromolecules · 2014Article
- Optimization of Tet1 ligand density in HPMA-co-oligolysine copolymers for targeted neuronal gene delivery.Biomaterials · 2013Article
- Engineering biodegradable and multifunctional peptide-based polymers for gene delivery.Journal of biological engineering · 2013Article
- Comparative study of guanidine-based and lysine-based brush copolymers for plasmid delivery.Biomaterials science · 2013Article
- Influence of histidine incorporation on buffer capacity and gene transfection efficiency of HPMA-co-oligolysine brush polymers.Biomacromolecules · 2013Article
- Melittin-grafted HPMA-oligolysine based copolymers for gene delivery.Biomaterials · 2013Article
- Optimization of brush-like cationic copolymers for nonviral gene delivery.Biomacromolecules · 2013Article
- Application of living free radical polymerization for nucleic acid delivery.Accounts of chemical research · 2012Article
- Reducible HPMA-co-oligolysine copolymers for nucleic acid delivery.International journal of pharmaceutics · 2012Article
- Cathepsin B-sensitive polymers for compartment-specific degradation and nucleic acid release.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
- The transduction of Coxsackie and Adenovirus Receptor-negative cells and protection against neutralizing antibodies by HPMA-co-oligolysine copolymer-coated adenovirus.Biomaterials · 2011Article
- HPMA-oligolysine copolymers for gene delivery: optimization of peptide length and polymer molecular weight.Journal of controlled release : official journal of the Controlled Release Society · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Our report describes RAFT copolymerization of multiple species of active peptide monomers with N-(2-hydroxypropyl(methacrylamide) (HPMA) under aqueous conditions. Resulting statistical copolymers are narrowly disperse with highly controlled molecular weight and composition. Side-chain peptide copolymers were synthesized using a DNA condensing peptide (K12), and an endosomal escape peptide (K6H5) that had been modified with an aminohexanoic linker and capped with methacrylamide vinyl on the NH2-terminus. Copolymers of HMPA-co-K12 and HPMA-co-K12-co-K6H5 efficiently condensed DNA into small particles that maintain size stability even in 150 mM salt solutions. With increasing peptide content, the peptide-based polymers demonstrated gene delivery efficiencies to HeLa cells that were comparable to branched polyethylenimine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.