ArticleJournal of experimental zoology. Part B, Molecular and developmental evolution2011
Modularity in the mammalian dentition: mice and monkeys share a common dental genetic architecture.
Article in Journal of experimental zoology. Part B, Molecular and developmental evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 86 citations in OpenAlex.
- 3D geometric morphometric analysis of morphological covariation in the modern human postcanine dentition.Scientific reports · 2026Article
- Quantitative Genetic Analysis of Baboon Facial Variation Challenges a Classic Papionin Trait.Integrative organismal biology (Oxford, England) · 2026Article
- Accommodation of Dental Variations During Jaw Growth in Ungulate Mammals.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Developmentally cascading structures do not lose evolutionary potential, but compound developmental instability in rat molars.bioRxiv : the preprint server for biology · 2025Article
- Tracking Molar Wear in Captive Baboons: Sex and Age Effects Using a Modified Scott Scoring System.American journal of biological anthropology · 2025Article
- Genetic Correlations Among Dental, Mandibular, and Postcranial Dimensions in Rhesus Macaques (Macaca mulatta).American journal of biological anthropology · 2025Article
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- Variation in Molar Size and Proportions in the Hominid Lineage: An Inter- and Intraspecific Approach.Integrative organismal biology (Oxford, England) · 2024Article
- Nutritional supplementation, tooth crown size, and trait expression in individuals from Tezonteopan, Mexico.PloS one · 2024Article
- Bat teeth illuminate the diversification of mammalian tooth classes.Nature communications · 2023Article
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- Genetic influences on dentognathic morphology in the Jirel population of Nepal.Anatomical record (Hoboken, N.J. : 2007) · 2022Article
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- A Plea for a New Synthesis: From Twentieth-Century Paleobiology to Twenty-First-Century Paleontology and Back Again.Biology · 2022Article
- Article
- Conserved and Taxon-Specific Patterns of Phenotypic Modularity in the Mammalian Dentition.Integrative organismal biology (Oxford, England) · 2022Article
- Folding Stability of Pax9 Intronic G-Quadruplex Correlates with Relative Molar Size in Eutherians.Molecular biology and evolution · 2021Article
- Genetic correlations in the rhesus macaque dentition.Journal of human evolution · 2020Article
- Neutral evolution of human enamel-dentine junction morphology.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The concept of modularity provides a useful tool for exploring the relationship between genotype and phenotype. Here, we use quantitative genetics to identify modularity within the mammalian dentition, connecting the genetics of organogenesis to the genetics of population-level variation for a phenotype well represented in the fossil record. We estimated the correlations between dental traits owing to the shared additive effects of genes (pleiotropy) and compared the pleiotropic relationships among homologous traits in two evolutionary distant taxa-mice and baboons. We find that in both mice and baboons, who shared a common ancestor >65 Ma, incisor size variation is genetically independent of molar size variation. Furthermore, baboon premolars show independent genetic variation from incisors, suggesting that a modular genetic architecture separates incisors from these posterior teeth as well. Such genetic independence between modules provides an explanation for the extensive diversity of incisor size variation seen throughout mammalian evolution-variation uncorrelated with equivalent levels of postcanine tooth size variation. The modularity identified here is supported by the odontogenic homeobox code proposed for the patterning of the rodent dentition. The baboon postcanine pattern of incomplete pleiotropy is also consistent with predictions from the morphogenetic field model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.