Evidence map›Paper›PMID 20922479›Full record

ArticlePharmacy world & science : PWS2010

The incidence of potential drug-drug interactions in elderly patients with arterial hypertension.

Vesna Bacic-Vrca, Srecko Marusic, Viktorija Erdeljic, Slaven Falamic, Nives Gojo-Tomic, Dario Rahelic

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pharmacy world & science : PWS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  5. Drug-drug interaction software in clinical practice: a systematic review.European journal of clinical pharmacology · 2015
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  14. Assessment of potential drug-drug interactions and its associated factors in the hospitalized cardiac patients.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vesna Bacic-VrcaDepartment of Clinical Pharmacy, University Hospital Dubrava, Zagreb, Croatia.
Srecko Marusic
Viktorija Erdeljic
Slaven Falamic
Nives Gojo-Tomic
Dario Rahelic

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the incidence and type of potential, clinically significant drug-drug interactions in elderly outpatients with arterial hypertension.

settingThree community pharmacies in Croatia.

methodEligible patients were aged 65 or older, treated for arterial hypertension and received 2 or more drugs. Potential interactions were identified by Lexi-Interact software. The software categorized each potential interaction according to clinical significance in five groups: (A) No known interaction; (B) Specified agents may interact, but there is little to no evidence of clinical concern; (C) Specified agents may interact in a clinically significant manner. Monitoring therapy is suggested; (D) The two medications may interact in a clinically significant manner. Modification of therapy is suggested; (X) Contraindicated combination. Interactions of level C, D and X were considered clinically significant.

main outcome measureThe incidence and type of potential drug-drug interactions.

resultsThere were 265 patients included in the study. Potential, clinically significant drug interactions were identified in 240 (90.6%) patients, out of which 97.9% had interactions with clinical significance C, 20.4% D, and 0.8% X. The median number of drug interactions per patient was 4. We identified 215 drug combinations with the potential to cause clinically significant interaction, out of which 83.3% had clinical significance C, 16.3% clinical significance D, and 0.4% clinical significance X.

conclusionDrug-drug interactions are common in elderly hypertensive patients. Computer-based screening could help pharmacists and physicians to recognize potential, clinically significant interactions.

Indexed as

Drug InteractionsAgedAged, 80 and overAge FactorsAntihypertensive AgentsCroatiaFemaleHumansHypertensionIncidenceMalePharmaciesProspective StudiesAntihypertensive Agents

Identifiers

PMID20922479

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.