ArticleVirchows Archiv : an international journal of pathology2010
Nasal seromucinous hamartoma (microglandular adenosis of the nose): a morphological and molecular study of five cases.
Article in Virchows Archiv : an international journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Sinonasal seromucinous hamartoma: a single institution case series combined with a narrative review of the literature.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Pooled it
- Expanding the genetic landscape of seromucinous hamartoma: novel HMGA2::PHF14 gene fusion - a case report.Virchows Archiv : an international journal of pathology · 2026Article
- Seromucinous Hamartoma of the Nasal Cavity: A Rare Entity Presenting a Diagnostic Challenge in Preoperative Biopsy.Diagnostics (Basel, Switzerland) · 2026Article
- Sinonasal adenoid cystic carcinomas accompanied by seromucinous hamartoma and/or atypical sinonasal glands arising from seromucinous hamartoma: insight into their histogenesis.Virchows Archiv : an international journal of pathology · 2025Article
- Histopathology of Chronic Rhinosinusitis and Sinonasal Inflammatory Polyps.Head and neck pathology · 2025Review
- Angiomyolipomatous Lesions of the Nasal Cavity (Sinonasal Angioleiomyoma with Adipocytic Differentiation): A Multi-Institutional Immunohistochemical and Molecular Study.Head and neck pathology · 2024Article
- Angiomyolipomatous Lesions of the Nasal Cavity (Sinonasal Angioleiomyoma with Adipocytic Differentiation): A Multi-Institutional Immunohistochemical and Molecular Study.Research square · 2024Article
- Nasal and sinonasal tumors formed by atypical adenomatous lesions arising in respiratory epithelial adenomatoid hamartoma/seromucinous hamartoma.Virchows Archiv : an international journal of pathology · 2024Article
- Seromucinous Hamartoma of the Lateral Nasal Wall with Infiltration of the Orbit: A Rare Case Report and Review of the Literature.Case reports in otolaryngology · 2023Article
- Hamartomatous Polyp of the Nasopharynx: A Rare Case Report.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2019Article
- Seromucinous Hamartoma of the Nasal Cavity.Head and neck pathology · 2019Article
- Seromucinous hamartoma of inferior turbinate: A case report.Medicine · 2018Article
- Sinonasal seromucinous hamartoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Article
- Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Nasal Cavity, Paranasal Sinuses and Skull Base.Head and neck pathology · 2017Article
- Low-Grade Epithelial Proliferations of the Sinonasal Tract.Head and neck pathology · 2016Review
- Recently described sinonasal tract lesions/neoplasms: considerations for the new world health organization book.Head and neck pathology · 2014Article
- Sinonasal seromucinous hamartoma: a review of the literature and a case report with focal myoepithelial cells.Head and neck pathology · 2012Review
- Seromucinous hamartoma of the nasal cavity: a report of two cases and review of the literature.Head and neck pathology · 2011Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Five cases of nasal seromucinous hamartoma were studied and their clinical, morphological, immunohistochemical and molecular data are reported. The patients, three females and two males, ranged in age from 49 to 66 years (mean 56 year, SD ± 7.91). All lesions were located in the nasal cavity. In four cases where follow-up was obtained, no recurrence was evident. In all cases, numerous small seromucinous tubules, embedded in a cellular stroma, were present in the lamina propria. Tubules were lined by one layer of cuboidal cells which displayed luminal phenotype positive for lysozyme and EMA in four, and S100 protein in all cases. Collagen IV and laminin positive basal lamina outlined the tubules which lacked basal cells. Stromal spindle cells present among tubules were immunoreactive for calponin in all cases and for alpha-smooth muscle actin in four cases. DNA mutation analysis of mitochondrial D-loop region was performed by direct sequencing in order to verify the mutation rate of these lesions. The tubules of the five seromucinous hamartomas showed a higher mutation rate especially in heteroplasmy (0.52% homoplasmy, 2.02% heteroplasmy) in comparison to normal seromucinous glands which exhibited a lower mutation frequency (0.83%). This is considered a sign of a low cellular proliferation rate consistent with a benign process. It is concluded that nasal seromucinous hamartomas are benign glandular proliferations that may resemble microglandular adenosis of the breast. Their distinction from benign and malignant mimics is discussed.
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