Evidence map›Paper›PMID 20921943›Full record

ArticleBone marrow transplantation2011

Delayed platelet recovery after allogeneic transplantation: a predictor of increased treatment-related mortality and poorer survival.

P Ramírez, C G Brunstein, B Miller, T Defor, D Weisdorf

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03408158 nacompletednot on this mapstarted 2017, after this paper: background citation

Multi-center Study in the Frequency of HPA Antibodies and the Distribution of Antigen and Antibodies in Chinese Blood Disease Patients

TypeinterventionalSponsorGuangzhou First People's HospitalRan2017 to 2020Enrolled6,170ConditionsBlood Disease, Platelet Refractoriness, Antibody-mediated RejectionArmssame type infusion of main HPA antigen
NCT05126004 phase2unknown statusnot on this mapstarted 2021, after this paper: background citation

Azacitidine (AZA) Combined With N-Acetyl-L-cysteine (NAC) for Prolonged Isolated Thrombocytopenia (PIT) After Hematopoietic Stem Cell Transplantation (HSCT)

TypeinterventionalSponsorThe First Affiliated Hospital of Soochow UniversityRan2021 to 2026Enrolled100ConditionsThrombocytopenia, Isolated, Stem Cell Transplant ComplicationsArmsAzacitidine, N Acetyl L Cysteine
3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

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  7. ABO mismatch is associated with increased nonrelapse mortality after allogeneic hematopoietic cell transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

P RamírezBlood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN, USA.
C G Brunstein
B Miller
T Defor
D Weisdorf

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Delayed platelet recovery (DPR) is common after allo-SCT. Insufficient data on risk factors and association with OS and TRM are available. We conducted a retrospective analysis of all allografts at the University of Minnesota between 2000 and 2005 to characterize the frequency of DPR (platelets <50 000/μL by day 60), risk factors and related complications. A total of 850 patients with hematological malignancies and benign disorders were included. Myeloablative (MA) conditioning was used in 65% of the patients and 45% received umbilical cord blood (UCB) grafts. The 60-day cumulative incidence of platelet recovery was 40% in UCB, 57% in unrelated donor (URD) and 74% in sibling donor. Multivariate analysis confirmed that the variables associated with DPR were MA (versus reduced intensity) conditioning, graft source other than sibling donor, ABO major mismatch, recipient CMV-positive serostatus, the presence of grade II-IV acute GVHD and slower neutrophil recovery. These data demonstrate that DPR is frequent after allogeneic hematopoietic cell transplantation, especially after UCB. DPR is a significant independent risk factor for increased TRM and poorer OS along with HLA-mismatched URD, but not UCB, grade II-IV acute GVHD, old age and advanced disease stage.

Indexed as

AdolescentAdultAgedBlood PlateletsChildChild, PreschoolCohort StudiesFemaleHematologic NeoplasmsHematopoietic Stem Cell TransplantationHumansInfantMaleMiddle AgedMinnesotaPlatelet Count

Identifiers

PMID20921943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.