ArticleGenetics in medicine : official journal of the American College of Medical Genetics2010
Generation after generation: exploring the psychological impact of providing genetic services through a cascading approach.
Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- The efficacy of genetic counseling for familial colorectal cancer: A meta-analysis.Journal of genetic counseling · 2025Pooled it
- Family Adjustment to Hereditary Cancer Syndromes: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- The psychological impact of genetic information on children: a systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Pooled it
- Exploring psychological responses to genetic testing for Lynch Syndrome within the family context.Psycho-oncology · 2014Article
- Genetics' influence on patient experiences with a rare chronic disorder: a photovoice study of living with alpha-1 antitrypsin deficiency.The Nursing clinics of North America · 2013Article
- The role of religious and existential well-being in families with Lynch syndrome: prevention, family communication, and psychosocial adjustment.Journal of genetic counseling · 2013Article
- Population sciences, translational research, and the opportunities and challenges for genomics to reduce the burden of cancer in the 21st century.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe provision of genetic services often occurs in a cascading fashion within families experiencing inherited diseases. This study examines whether previous family experiences with genetic services influences levels of psychological well-being of family members receiving services later.
methodsTwo hundred ninety-seven persons from 38 families with Lynch syndrome completed questionnaires before receiving genetic services. Baseline levels of test-related distress, depressive symptoms, and cancer worries were assessed in relationship to the (1) amount of time elapsed since services were provided to the index case and (2) generation of the family member relative to the index case.
resultsFamily members in the same generation as the index case experienced significant increases in test-related distress (P = 0.003) and cancer worry (P = 0.001) with increasing time between receipt of genetic test results by the index case and provision of services to family members. Change in the number of depressive symptoms was not significant (P = 0.17).
conclusionThe provision of genetic services through a cascading approach significantly increases distress and worry among family members within the same generation as the index case who receive services at increasingly distant time intervals. Additional research is needed to explore social influences after the introduction of genetic services.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.