Trial reportAnnals of internal medicine2010
Insufficient sleep undermines dietary efforts to reduce adiposity.
Trial report in Annals of internal medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
160 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Sleep and Its Impact on the Success of Weight Loss Interventions in Adults With Excess Weight: A Systematic Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Mapping smart technologies and nutritional strategies for monitoring cognitive resilience in military personnel under extreme operational conditions: a scoping review.Frontiers in nutrition · 2026Pooled it
- Impact of artificial light at night on obesity and overweight: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Gut microbiome changes due to sleep disruption in older and younger individuals: a case for sarcopenia?Sleep · 2022Pooled it
- Experimental sleep restriction effect on adult body weight: a meta-analysis.Sleep & breathing = Schlaf & Atmung · 2019Pooled it
- Association of sleep duration and quality with blood lipids: a systematic review and meta-analysis of prospective studies.BMJ open · 2017Pooled it
- TRIB1 constitutes a molecular link between regulation of sleep and lipid metabolism in humans.Translational psychiatry · 2012Pooled it
- From plate to pillow, and vice versa: diet-sleep dynamics in free-living adults with obesity.European journal of nutrition · 2026Trial
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- Effect of sleep on weight loss and adherence to diet and physical activity recommendations during an 18-month behavioral weight loss intervention.International journal of obesity (2005) · 2022Trial
- Sleep Disturbance and Changes in Energy Intake and Body Composition During Weight Loss in the POUNDS Lost Trial.Diabetes · 2022Trial
- Examining Sleep Quality Following Sleeve Gastrectomy Among Patients with Loss-of-Control Eating.Obesity surgery · 2019Trial
- Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans.Science advances · 2018Trial
- Influence of sleep restriction on weight loss outcomes associated with caloric restriction.Sleep · 2018Trial
- Lifestyle Intervention for Sleep Disturbances Among Overweight or Obese Individuals.Behavioral sleep medicine · 2016Trial
- Resting metabolic rate varies by race and by sleep duration.Obesity (Silver Spring, Md.) · 2015Trial
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- Experimental sleep curtailment causes wake-dependent increases in 24-h energy expenditure as measured by whole-room indirect calorimetry.The American journal of clinical nutrition · 2013Trial
- Effects of sleep restriction on the human plasma metabolome.Physiology & behavior · 2013Trial
100 more citing papers are in PubMed but not listed here.
Corrections and comments
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- SummaryForPatientsIn
Authors and funding
5 authors.
Funding
Abstract
backgroundSleep loss can modify energy intake and expenditure.
objectiveTo determine whether sleep restriction attenuates the effect of a reduced-calorie diet on excess adiposity.
designRandomized, 2-period, 2-condition crossover study.
settingUniversity clinical research center and sleep laboratory. PATIENTS: 10 overweight nonsmoking adults (3 women and 7 men) with a mean age of 41 years (SD, 5) and a mean body mass index of 27.4 kg/m² (SD, 2.0).
intervention14 days of moderate caloric restriction with 8.5 or 5.5 hours of nighttime sleep opportunity. MEASUREMENTS: The primary measure was loss of fat and fat-free body mass. Secondary measures were changes in substrate utilization, energy expenditure, hunger, and 24-hour metabolic hormone concentrations.
resultsSleep curtailment decreased the proportion of weight lost as fat by 55% (1.4 vs. 0.6 kg with 8.5 vs. 5.5 hours of sleep opportunity, respectively; P = 0.043) and increased the loss of fat-free body mass by 60% (1.5 vs. 2.4 kg; P = 0.002). This was accompanied by markers of enhanced neuroendocrine adaptation to caloric restriction, increased hunger, and a shift in relative substrate utilization toward oxidation of less fat. LIMITATION: The nature of the study limited its duration and sample size.
conclusionThe amount of human sleep contributes to the maintenance of fat-free body mass at times of decreased energy intake. Lack of sufficient sleep may compromise the efficacy of typical dietary interventions for weight loss and related metabolic risk reduction. PRIMARY FUNDING SOURCE: National Institutes of Health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.