ArticleProceedings of the National Academy of Sciences of the United States of America2010
Somatic sex determination in Caenorhabditis elegans is modulated by SUP-26 repression of tra-2 translation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Identification of BiP as a temperature sensor mediating temperature-induced germline sex reversal in C. elegans.The EMBO journal · 2024Article
- Identification of BiP as a temperature sensor mediating temperature-induced germline sex reversal in C. elegans.The EMBO journal · 2024Article
- Regulators of male and female sexual development are critical for the transmission of a malaria parasite.Cell host & microbe · 2023Article
- Sex Determination in Nematode Germ Cells.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2022Review
- Sense-overlapping lncRNA as a decoy of translational repressor protein for dimorphic gene expression.PLoS genetics · 2021Article
- Identification and Functional Analysis of the Sex-DeterminerFrontiers in physiology · 2021Article
- Molecular Effects of Silver Nanoparticles on Monogenean Parasites: Lessons fromInternational journal of molecular sciences · 2020Article
- Dietary restriction induces posttranscriptional regulation of longevity genes.Life science alliance · 2019Article
- TheG3 (Bethesda, Md.) · 2019Article
- Multi-modal regulation of C. elegans hermaphrodite spermatogenesis by the GLD-1-FOG-2 complex.Developmental biology · 2019Article
- A microRNA family exerts maternal control on sex determination inGenes & development · 2017Article
- Translation readthrough mitigation.Nature · 2016Article
- Drosophila Shep and C. elegans SUP-26 are RNA-binding proteins that play diverse roles in nervous system development.Development genes and evolution · 2015Article
- microRNA regulation of the embryonic hypoxic response in Caenorhabditis elegans.Scientific reports · 2015Article
- Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons.G3 (Bethesda, Md.) · 2015Article
- A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells.Nature communications · 2015Article
- Evolutionary Dynamics of GLD-1-mRNA complexes in Caenorhabditis nematodes.Genome biology and evolution · 2014Article
- The embryonic mir-35 family of microRNAs promotes multiple aspects of fecundity in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2014Article
- TRA-1 ChIP-seq reveals regulators of sexual differentiation and multilevel feedback in nematode sex determination.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Independent recruitments of a translational regulator in the evolution of self-fertile nematodes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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4 authors at 2 institutions in 3 countries.
Funding
Abstract
Translational repression mediated by RNA-binding proteins or micro RNAs has emerged as a major regulatory mechanism for fine-tuning important biological processes. In Caenorhabditis elegans, translational repression of the key sex-determination gene tra-2 (tra, transformer) is controlled by a 28-nucleotide repeat element, the TRA-2/GLI element (TGE), located in its 3' untranslated region (UTR). Mutations that disrupt TGE or the germline-specific TGE-binding factor GLD-1 increase TRA-2 protein expression and inhibit sperm production in hermaphrodites. Here we report the characterization of the sup-26 gene, which regulates sex determination in the soma and encodes an RNA recognition motif (RRM)-containing protein. We show that SUP-26 regulates the level of the TRA-2 protein through TGE in vivo and binds directly to TGE in vitro through its RRM domain. Interestingly, SUP-26 associates with poly(A)-binding protein 1 (PAB-1) in vivo and may repress tra-2 expression by inhibiting the translation-stimulating activity of PAB-1. Taken together, our results provide further insight into how mRNA-binding factors repress translation and modulate sexual development in different tissues of C. elegans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.