ArticleProceedings of the National Academy of Sciences of the United States of America2010
Injectable hydrogel microbeads for fluorescence-based in vivo continuous glucose monitoring.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
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Who cites it
75 citing papers in PubMed.
- A wearable closed-loop insulin micropump toward a miniaturized artificial pancreas for diabetes.Microsystems & nanoengineering · 2026Article
- Augmenting ultrasound for continuous glucose monitoring via a wearable acoustically readable microneedle patch.Science advances · 2026Article
- A flexible wireless skin patch for synchronized glucose monitoring and regulation.Microsystems & nanoengineering · 2026Article
- Multicolor management of smart fluorescent polymeric hydrogels.Fundamental research · 2025Review
- Glucose Sensor Design Based on Monte Carlo Simulation.Biosensors · 2025Article
- Fluorescent Chemosensors in the Creation of a Commercially Available Continuous Glucose Monitor.ACS sensors · 2024Article
- Microfluidic-based systems for the management of diabetes.Drug delivery and translational research · 2024Review
- Engineered Bacteria as Living Biosensors in Dermal Tattoos.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Wearing the Lab: Advances and Challenges in Skin-Interfaced Systems for Continuous Biochemical Sensing.Advances in biochemical engineering/biotechnology · 2024Review
- Recent Insights about the Role of Gels in Organic Photonics and Electronics.Gels (Basel, Switzerland) · 2023Review
- β-Tricalcium Phosphate-Loaded Chitosan-Based Thermosensitive Hydrogel for Periodontal Regeneration.Polymers · 2023Article
- Fluorescent-based biodegradable microneedle sensor array for tether-free continuous glucose monitoring with smartphone application.Science advances · 2023Article
- Catalytic Modification of Porous Two-Dimensional Ni-MOFs on Portable Electrochemical Paper-Based Sensors for Glucose and Hydrogen Peroxide Detection.Biosensors · 2023Article
- Facile Obtainment of Fluorescent PEG Hydrogels Bearing Pyrene Groups by Frontal Polymerization.Polymers · 2023Article
- Continuous Glucose Monitoring Enabled by Fluorescent Nanodiamond Boronic Hydrogel.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Engineered biomimetic micro/nano-materials for tissue regeneration.Frontiers in bioengineering and biotechnology · 2023Review
- Adipose Fin as a Natural "Optical Window" for Implantation of Fluorescent Sensors into Salmonid Fish.Animals : an open access journal from MDPI · 2022Article
- Article
- Engineering of Immune Microenvironment for Enhanced Tissue Remodeling.Tissue engineering and regenerative medicine · 2022Review
- Comprehensive Review on Wearable Sweat-Glucose Sensors for Continuous Glucose Monitoring.Sensors (Basel, Switzerland) · 2022Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescent microbeads hold great promise for in vivo continuous glucose monitoring with wireless transdermal transmission and long-lasting activity. The full potential of fluorescent microbeads has yet to be realized due to insufficient intensity for transdermal transmission and material toxicity. This paper illustrates the highly-sensitive, biostable, long-lasting, and injectable fluorescent microbeads for in vivo continuous glucose monitoring. We synthesized a fluorescent monomer composed of glucose-recognition sites, a fluorogenic site, spacers, and polymerization sites. The spacers are designed to be long and hydrophilic for increasing opportunities to bind glucose molecules; consequently, the fluorescent monomers enable high-intensive responsiveness to glucose. We then fabricated injectable-sized fluorescent polyacrylamide hydrogel beads with high uniformity and high throughput. We found that our fluorescent beads provide sufficient intensity to transdermally monitor glucose concentrations in vivo. The fluorescence intensity successfully traced the blood glucose concentration fluctuation, indicating our method has potential uses in highly-sensitive and minimally invasive continuous blood glucose monitoring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.