ArticleAntimicrobial agents and chemotherapy2010
Efficacy of a doxycycline treatment regimen initiated during three different phases of experimental ehrlichiosis.
Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 54 citations in OpenAlex.
- The efficacy of a generic doxycycline tablet in the treatment of canine monocytic ehrlichiosis.Journal of the South African Veterinary Association · 2015Trial
- Comparative efficacy of once-daily versus twice-daily doxycycline regimens in dogs naturally infected withVeterinary and animal science · 2026Article
- Molecular prevalence ofParasite epidemiology and control · 2026Article
- Differential causes of masticatory muscle disorders in dogs: a review of diagnosis, treatment and long-term management.Frontiers in veterinary science · 2026Review
- Seroprevalence ofVeterinary sciences · 2025Article
- Effects of Doxycycline Treatment on Hematological Parameters, Viscosity, and Cytokines in Canine Monocytic Ehrlichiosis.Biology · 2023Article
- Ehrlichiosis in Dogs: A Comprehensive Review about the Pathogen and Its Vectors with Emphasis on South and East Asian Countries.Veterinary sciences · 2022Review
- Ehrlichia canis in dogs experimentally infected, treated, and then immune suppressed during the acute or subclinical phases.Journal of veterinary internal medicine · 2020Article
- Prevalence of canine Babesia and Ehrlichia co-infection and the predictive value of haematology.The Onderstepoort journal of veterinary research · 2018Article
- A Bayesian spatio-temporal model for forecasting the prevalence of antibodies to Ehrlichia species in domestic dogs within the contiguous United States.Parasites & vectors · 2017Article
- Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe.Parasites & vectors · 2015Review
- Article
- Experimental infection of Rhipicephalus sanguineus with Ehrlichia chaffeensis.Veterinary microbiology · 2014Article
- Integrated transcriptomic and proteomic analysis of the global response of Wolbachia to doxycycline-induced stress.The ISME journal · 2014Article
- Seropositivity rates for agents of canine vector-borne diseases in Spain: a multicentre study.Parasites & vectors · 2013Article
- Ehrlichiosis, babesiosis, anaplasmosis and hepatozoonosis in dogs from St. Kitts, West Indies.PloS one · 2013Article
- Estimated seroprevalence of Ehrlichia canis in dogs in a remote community in the Northern Territory, Australia.Australian veterinary journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Doxycycline is the treatment of choice for canine monocytic ehrlichiosis (CME), a well-characterized disease and valuable model for tick-borne zoonoses. Conflicting reports of clearance of Ehrlichia canis after treatment with doxycycline suggested that the disease phase during which treatment is initiated influences outcomes of these treatments. The purpose of this study was to evaluate the efficacy of a 28-day doxycycline regimen for clearance of experimental E. canis infections from dogs treated during three phases of the disease. Ten dogs were inoculated with blood from E. canis carriers and treated with doxycycline during acute, subclinical, or chronic phases of CME. Daily rectal temperatures and semiweekly blood samples were monitored from each dog, and Rhipicephalus sanguineus ticks were acquisition fed on each dog for xenodiagnosis. Blood collected from dogs treated during acute or subclinical CME became PCR negative for E. canis as clinical parameters improved, but blood samples collected from dogs treated during chronic CME remained intermittently PCR positive. R. sanguineus ticks fed on dogs after doxycycline treatments became PCR positive for E. canis, regardless of when treatment was initiated. However, fewer ticks became PCR positive after feeding on two persistently infected dogs treated with doxycycline followed by rifampin, suggesting that antibiotic therapy can reduce tick acquisition of E. canis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.