ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2010
Adenosine signaling via the adenosine 2B receptor is involved in bronchiolitis obliterans development.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Adenosine-mediated immune responses in inflammatory bowel disease.Frontiers in cell and developmental biology · 2024Review
- Lungs donated after circulatory death and prolonged warm ischemia are transplanted successfully after enhanced ex vivo lung perfusion using adenosine A2B receptor antagonism.The Journal of thoracic and cardiovascular surgery · 2017Article
- A novel chronic advanced stage abdominal aortic aneurysm murine model.Journal of vascular surgery · 2017Article
- Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia.Experimental lung research · 2017Article
- Airway pressure release ventilation during ex vivo lung perfusion attenuates injury.The Journal of thoracic and cardiovascular surgery · 2017Article
- Advanced Role of Neutrophils in Common Respiratory Diseases.Journal of immunology research · 2017Review
- Donation After Circulatory Death Lungs Transplantable Up to Six Hours After Ex Vivo Lung Perfusion.The Annals of thoracic surgery · 2016Article
- Unlocking the Potential of Purinergic Signaling in Transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016Review
- Rapamycin prevents bronchiolitis obliterans through increasing infiltration of regulatory B cells in a murine tracheal transplantation model.The Journal of thoracic and cardiovascular surgery · 2016Article
- Revascularization of the graft in obliterative bronchiolitis after heterotopic tracheal transplantation.Physiological reports · 2016Article
- Dietary phytoestrogens inhibit experimental aneurysm formation in male mice.The Journal of surgical research · 2014Article
- The Role of Ectonucleotidases CD39 and CD73 and Adenosine Signaling in Solid Organ Transplantation.Frontiers in immunology · 2014Review
- Rapamycin blocks fibrocyte migration and attenuates bronchiolitis obliterans in a murine model.The Annals of thoracic surgery · 2013Article
- Prevention of the second stage of epithelial loss is a potential novel treatment for bronchiolitis obliterans.The Journal of thoracic and cardiovascular surgery · 2013Article
- Inhibiting CXCL12 blocks fibrocyte migration and differentiation and attenuates bronchiolitis obliterans in a murine heterotopic tracheal transplant model.The Journal of thoracic and cardiovascular surgery · 2013Article
- Adenosine signaling during acute and chronic disease states.Journal of molecular medicine (Berlin, Germany) · 2013Review
- Differential gender- and species-specific formation of aneurysms using a novel method of inducing abdominal aortic aneurysms.The Journal of surgical research · 2012Article
- Increased PAI-1 in females compared with males is protective for abdominal aortic aneurysm formation in a rodent model.American journal of physiology. Heart and circulatory physiology · 2012Article
- Regulation of leukocyte function by adenosine receptors.Advances in pharmacology (San Diego, Calif.) · 2011Review
- Animal models of airway diseases.Sub-cellular biochemistry · 2011Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAdenosine is produced in response to ischemia or inflammation and protects tissues from injury. Four adenosine receptors are critical in the physiologic negative-feedback mechanism for limitation and termination of tissue-specific and systemic inflammatory responses. Accumulating evidence has focused on the anti-inflammatory and immunosuppressive role of the adenosine 2A receptor (A(2A)R), and we have previously reported on its role in the development of bronchiolitis obliterans (BO) after lung transplantation. Few studies, however, have reported the role of the adenosine 2B receptor (A(2B)R) in BO. Data suggests that the A(2B)R has pro-inflammatory and pro-fibrotic roles. We hypothesized that adenosine signaling through A(2B)R is involved in the development of BO.
methodsA murine heterotopic tracheal model across a total alloantigenic mismatch was used to study A(2B)R signaling in BO. Tracheal transplants consisted of Balb/c donor tracheas transplanted into wild-type or A(2B)R knockout (KO) C57BL/6 recipients. Transplanted tracheas were removed 3, 7, 12, and 21 days after transplantation. The luminal obliteration was evaluated through hematoxylin and eosin staining, and the cellular infiltration (macrophage, neutrophil, CD3+ and Foxp3+ regulatory T cell) was detected by immunohistochemical staining.
resultsCompared with allografts in wild-type recipients, tracheas transplanted into A(2B)R KO mice displayed less BO development on Day 21. A(2B)R KO mice had an increase in CD3+ T cells and CD4+/CD25+/Foxp3+ regulatory T cells than did wild-type mice on Day 7. By Day 12, more CD3+ T cells were present in the wild-type trachea compared with the A(2B)R KO, but the percentage of CD4+/CD25+/Foxp3+ regulatory T cells remained higher in the tracheas of A(2B)R KO mice.
conclusionsA(2B)R stimulation may promote the development of BO by inhibiting CD4+/CD25+/Foxp3+ regulatory T-cell infiltration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.