ArticleNeuron2010
Presynaptic activity and CaMKII modulate retrograde semaphorin signaling and synaptic refinement.
Article in Neuron, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 55 citations in OpenAlex.
- Local Synthesis of CaMKII Does Not Contribute to Activity-Dependent Generation of Ghost Boutons.eNeuro · 2026Article
- The mechanotransduction channel Piezo2 refines axonal projections to the accessory optic system and regulates the optokinetic reflex.bioRxiv : the preprint server for biology · 2026Article
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- hkb is required for DIP-α expression and target recognition in the Drosophila neuromuscular circuit.Communications biology · 2024Article
- CaMKII mediates sexually dimorphic synaptic transmission at neuromuscular junctions in C. elegans.The Journal of cell biology · 2023Article
- Neuronal guidance genes in health and diseases.Protein & cell · 2023Review
- UNC-43/CaMKII-triggered anterograde signals recruit GABANature communications · 2023Article
- Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins.International journal of molecular sciences · 2021Review
- Tyramine induces dynamic RNP granule remodeling and translation activation in the Drosophila brain.eLife · 2021Article
- Structural and Functional Synaptic Plasticity Induced by Convergent Synapse Loss in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- A comparison of three different methods of eliciting rapid activity-dependent synaptic plasticity at the Drosophila NMJ.PloS one · 2021Article
- Synaptic Plasticity Induced by Differential Manipulation of Tonic and Phasic Motoneurons inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Synaptic Properties and Plasticity Mechanisms of Invertebrate Tonic and Phasic Neurons.Frontiers in physiology · 2020Review
- Activity-Dependent Synaptic Plasticity inFrontiers in physiology · 2020Review
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- Article
- Plexin-Semaphorin Signaling Modifies Neuromuscular Defects in aFrontiers in molecular neuroscience · 2018Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Establishing synaptic connections often involves the activity-dependent withdrawal of off-target contacts. We describe an in vivo role for temporally patterned electrical activity, voltage-gated calcium channels, and CaMKII in modulating the response of Drosophila motoneurons to the chemorepellent Sema-2a during synaptic refinement. Mutations affecting the Sema-2a ligand, the plexin B receptor (plexB), the voltage-gated Ca(v)2.1 calcium channel (cac), or the voltage-gated Na(v)1 sodium channel (mle(nap-ts);tipE) each result in ectopic neuromuscular contacts. Sema-2a interacts genetically with both of the channel mutations. The cac phenotype is enhanced by the Sema-2a mutation and is suppressed by either plexB overexpression or patterned, low-frequency (0.01 Hz) bouts of electrical activity in the embryo. The calcium-dependent suppression of ectopic contacts also depends on the downstream activation of CaMKII. These results indicate a role for patterned electrical activity and presynaptic calcium signaling, acting through CaMKII, in modulating a retrograde signal during the refinement of synaptic connections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.