ArticleNeuropsychologia2011
The amygdala and decision-making.
Article in Neuropsychologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impulsivity, Compulsivity, Social Inappropriateness, and Other Neuropsychiatric Features in Cerebellar Histiocytosis.Cerebellum (London, England) · 2026Pooled it
- Neural correlates of implicit emotion regulation in mood and anxiety disorders: an fMRI meta-analytic review.Scientific reports · 2025Pooled it
- How Do Simulated Error Experiences Impact Attitudes Related to Error Prevention?Simulation in healthcare : journal of the Society for Simulation in Healthcare · 2016Trial
- Role of the Amygdala in the Complex Relationship Between Sleep and Anxiety.International journal of molecular sciences · 2026Review
- The Amygdala and Politics.Brain sciences · 2026Review
- Reward and punishment learning among people with a lifetime history of anxiety, depression, and substance use disorder.Cognitive, affective & behavioral neuroscience · 2025Article
- Brain-Pupil Coupling Revealed Through Deep Learning of Intracranial Recordings.Human brain mapping · 2025Article
- Reward circuit local field potential modulations precede risk taking.Brain : a journal of neurology · 2025Article
- Born to Fear the Machine? Genetic and Environmental Influences on Negative Attitudes toward AI Agents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Age-related dysregulation of proteasome-independent K63 polyubiquitination in the hippocampus and amygdala.Neuroscience · 2025Article
- Exploring Emotional Conflicts and Pain Experience in Patients with Non-Specific Chronic Neck Pain: A Qualitative Study.Journal of clinical medicine · 2025Article
- Aberrant glutamatergic systems underlying impulsive behaviors: Insights from clinical and preclinical research.Progress in neuro-psychopharmacology & biological psychiatry · 2024Review
- Mapping the Neural Basis of Neuroeconomics with Functional Magnetic Resonance Imaging: A Narrative Literature Review.Brain sciences · 2024Review
- Neuroendocrine and cellular mechanisms in stress resilience: From hormonal influence in the CNS to mitochondrial dysfunction and oxidative stress.Journal of cellular and molecular medicine · 2024Review
- Amphetamine use disorder is associated with striatum hypoactivation during anticipation of loss and reward.Journal of psychopharmacology (Oxford, England) · 2024Article
- Friendship changes differentially predict neural correlates of decision-making for friends across adolescence.Developmental cognitive neuroscience · 2024Article
- Reduced grey matter volume in adolescents with conduct disorder: a region-of-interest analysis using multivariate generalized linear modeling.Discover mental health · 2023Article
- Reduced Grey Matter Volume in Adolescents with Conduct Disorder: A Region-of-Interest Analysis Using Multivariate Generalized Linear Modeling.Research square · 2023Article
- Distinct neural activations correlate with maximization of reward magnitude versus frequency.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Multiple routes of communication within the amygdala-mPFC network: A comparative approach in humans and macaques.Current research in neurobiology · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Decision-making is a complex process that requires the orchestration of multiple neural systems. For example, decision-making is believed to involve areas of the brain involved in emotion (e.g., amygdala, ventromedial prefrontal cortex) and memory (e.g., hippocampus, dorsolateral prefrontal cortex). In this article, we will present findings related to the amygdala's role in decision-making, and differentiate the contributions of the amygdala from those of other structurally and functionally connected neural regions. Decades of research have shown that the amygdala is involved in associating a stimulus with its emotional value. This tradition has been extended in newer work, which has shown that the amygdala is especially important for decision-making, by triggering autonomic responses to emotional stimuli, including monetary reward and punishment. Patients with amygdala damage lack these autonomic responses to reward and punishment, and consequently, cannot utilize "somatic marker" type cues to guide future decision-making. Studies using laboratory decision-making tests have found deficient decision-making in patients with bilateral amygdala damage, which resembles their real-world difficulties with decision-making. Additionally, we have found evidence for an interaction between sex and laterality of amygdala functioning, such that unilateral damage to the right amygdala results in greater deficits in decision-making and social behavior in men, while left amygdala damage seems to be more detrimental for women. We have posited that the amygdala is part of an "impulsive," habit type system that triggers emotional responses to immediate outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.