ArticleNeuropsychologia2011
The human amygdala is necessary for developing and expressing normal interpersonal trust.
Article in Neuropsychologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- The Role of the Amygdala in Facial Trustworthiness Processing: A Systematic Review and Meta-Analyses of fMRI Studies.PloS one · 2016Pooled it
- Opioid receptor blockade and warmth-liking: effects on interpersonal trust and frontal asymmetry.Social cognitive and affective neuroscience · 2014Trial
- Serotoninergic effects on judgments and social learning of trustworthiness.Psychopharmacology · 2014Trial
- A neural signature of affiliative emotion in the human septohypothalamic area.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Trial
- Betrayal and unfairness are linked through insula-valuation network dynamics.bioRxiv : the preprint server for biology · 2026Article
- Associations between negative symptoms and resting-state functional connectivity within social brain networks among individuals with early psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Childhood adversity and health: The mediating roles of emotional expression and general trust.Frontiers in psychology · 2024Article
- Every individual makes a difference: A trinity derived from linking individual brain morphometry, connectivity and mentalising ability.Human brain mapping · 2023Article
- Trust or Distrust: The Effect of Facial Emotion and Trustworthy Behavior on Trust Decision-Making.Psychologica Belgica · 2023Article
- Does rDLPFC activity alter trust? Evidence from a tDCS study.Frontiers in neuroscience · 2023Article
- The neuroanatomy of social trust predicts depression vulnerability.Scientific reports · 2022Article
- Functional Neuroimaging of Human Hypothalamus in Socioemotional Behavior: A Systematic Review.Brain sciences · 2022Review
- Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Amygdala hyperconnectivity in the paranoid state: A transdiagnostic study.Journal of psychiatric research · 2021Article
- Hierarchical Neural Prediction of Interpersonal Trust.Neuroscience bulletin · 2021Article
- Connectome-based model predicts individual differences in propensity to trust.Human brain mapping · 2019Article
- Left Amygdala and Putamen Activation Modulate Emotion Driven Decisions in the Iterated Prisoner's Dilemma Game.Frontiers in neuroscience · 2019Article
- Oxytocin Facilitates Social Learning by Promoting Conformity to Trusted Individuals.Frontiers in neuroscience · 2019Review
- Association of the oxytocin receptor gene with attitudinal trust: role of amygdala volume.Social cognitive and affective neuroscience · 2018Article
- Heart rate variability is associated with social value orientation in males but not females.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The human amygdala is known to be involved in processing social, emotional, and reward-related information. Previous reports have indicated that the amygdala is involved in extracting trustworthiness information from faces. Interestingly, functional neuroimaging research using economic tasks that presumably require developing and/or expressing interpersonal trust, such as the Trust Game (TG), have not routinely identified involvement of the amygdala. The present study sought to explore the role of the amygdala in developing and expressing interpersonal trust, via a multi-round, multiplayer economic exchange, a version of the TG, in a large sample of participants with focal brain damage. Participants with unilateral damage to the amygdala displayed increased benevolent behavior in the TG, and specifically, they tended to increase trust in response to betrayals. On the other hand, neurologically normal adults tended to repay trust in kind, i.e., they decreased interpersonal trust in response to betrayals or increased trust in response to increases from others. Comparison participants, with brain damage that does not include the amygdala, ventromedial prefrontal or insular cortices, tended to behave ambivalently to the expressed trust or betrayal of others. Our data suggest that the amygdala is necessary for developing and expressing normal interpersonal trust. This increased tendency to behave benevolently in response to defections from others may be related to the abnormal social behavior observed in this group. Moreover, increased benevolence may increase the likelihood or opportunity to be taken advantage of by others.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.