ArticleDevelopmental biology2010
Mice lacking FABP9/PERF15 develop sperm head abnormalities but are fertile.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Insulin Resistance and Inflammation.International journal of molecular sciences · 2026Review
- A high-resolution data set of fatty acid-binding protein structures. II. Crystallographic overview, ligand classes and binding pose.Acta crystallographica. Section D, Structural biology · 2025Article
- Proteomic analysis of fipronil-induced molecular defects in spermatozoa.Scientific reports · 2024Article
- Bifenthrin Diminishes Male Fertility Potential by Inducing Protein Defects in Mouse Sperm.Toxics · 2024Article
- scapGNN: A graph neural network-based framework for active pathway and gene module inference from single-cell multi-omics data.PLoS biology · 2023Article
- The Multifunctional Family of Mammalian Fatty Acid-Binding Proteins.Annual review of nutrition · 2023Review
- Decay of Skin-Specific Gene Modules in Pangolins.Journal of molecular evolution · 2023Article
- Fetal Exposure to Endocrine Disrupting-Bisphenol A (BPA) Alters Testicular Fatty Acid Metabolism in the Adult Offspring: Relevance to Sperm Maturation and Quality.International journal of molecular sciences · 2023Article
- Marginal Zinc Deficiency in Mice Increased the Number of Abnormal Sperm and Altered the Expression Level of Spermatogenesis-Related Genes.Biological trace element research · 2022Article
- Influence of Risk Factors for Male Infertility on Sperm Protein Composition.International journal of molecular sciences · 2021Review
- Biological Roles of Lipocalins in Chemical Communication, Reproduction, and Regulation of Microbiota.Frontiers in physiology · 2021Review
- Article
- Complete Inactivation of Sebum-Producing Genes Parallels the Loss of Sebaceous Glands in Cetacea.Molecular biology and evolution · 2019Article
- Patterns of host gene expression associated with harboring a foregut microbial community.BMC genomics · 2017Article
- Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice.Oxidative medicine and cellular longevity · 2016Article
- Soy isoflavones in nutritionally relevant amounts have varied nutrigenomic effects on adipose tissue.Molecules (Basel, Switzerland) · 2015Article
- FABP9 Mutations Are Not Detected in Cases of Infertility due to Sperm Morphological Defects in Iranian Men.International journal of fertility & sterility · 2014Article
- Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis.Endocrinology · 2014Article
- Thiol changes during epididymal maturation: a link to flagellar angulation in mouse spermatozoa?Andrology · 2014Article
- Phospholipase B is activated in response to sterol removal and stimulates acrosome exocytosis in murine sperm.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The male germ cell-specific fatty acid-binding protein 9 (FABP9/PERF15) is the major component of the murine sperm perforatorium and perinuclear theca. Based on its cytoskeletal association and sequence homology to myelin P2 (FABP8), it has been suggested that FABP9 tethers sperm membranes to the underlying cytoskeleton. Furthermore, its upregulation in apoptotic testicular germ cells and its increased phosphorylation status during capacitation suggested multiple important functions for FABP9. Therefore, we investigated specific functions for FABP9 by means of targeted gene disruption in mice. FABP9(-/-) mice were viable and fertile. Phenotypic analysis showed that FABP9(-/-) mice had significant increases in sperm head abnormalities (~8% greater than their WT cohorts); in particular, we observed the reduction or absence of the characteristic structural element known as the "ventral spur" in ~10% of FABP9(-/-) sperm. However, deficiency of FABP9 affected neither membrane tethering to the perinuclear theca nor the fatty acid composition of sperm. Moreover, epididymal sperm numbers were not affected in FABP9(-/-) mice. Therefore, we conclude that FABP9 plays only a minor role in providing the murine sperm head its characteristic shape and is not absolutely required for spermatogenesis or sperm function.
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