Evidence map›Paper›PMID 20920356›Full record

ArticleBMC research notes2010

aeGEPUCI: a database of gene expression in the dengue vector mosquito, Aedes aegypti.

Sumudu N Dissanayake, Jose Mc Ribeiro, Mei-Hui Wang, William A Dunn, Guiyun Yan, Anthony A James, Osvaldo Marinotti

Abstract read
In one paragraph

Article in BMC research notes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

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  12. Frontiers in cellular and infection microbiology · 2019
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  19. Meta-Analysis ofFrontiers in bioengineering and biotechnology · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sumudu N DissanayakeDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA. omarinot@uci.edu.
Jose Mc Ribeiro
Mei-Hui Wang
William A Dunn
Guiyun Yan
Anthony A James
Osvaldo Marinotti

Funding

Vector-Borne Diseases: Biology Of Vector Host RelationshipZIAAI000810 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI RIBEIRO, JOSE · 2009 to 2025
$20.8M
Research Training in Mosquito Genomics and Bioinformat*D43TW001505 · FIC · UNIVERSITY OF CALIFORNIA-IRVINE · PI Guiyun Yan · 2000 to 2026
$6.0M
EXPRESSION OF EXOGENOUS GENES IN VECTOR MOSQUITOESR01AI029746 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JAMES, ANTHONY A. · 1989 to 2006
$1.7M
FIC NIH HHS D43 TW001505NIAID NIH HHS R01 AI029746
6 · The paper itself

Abstract

backgroundAedes aegypti is the principal vector of dengue and yellow fever viruses. The availability of the sequenced and annotated genome enables genome-wide analyses of gene expression in this mosquito. The large amount of data resulting from these analyses requires efficient cataloguing before it becomes useful as the basis for new insights into gene expression patterns and studies of the underlying molecular mechanisms for generating these patterns.

findingsWe provide a publicly-accessible database and data-mining tool, aeGEPUCI, that integrates 1) microarray analyses of sex- and stage-specific gene expression in Ae. aegypti, 2) functional gene annotation, 3) genomic sequence data, and 4) computational sequence analysis tools. The database can be used to identify genes expressed in particular stages and patterns of interest, and to analyze putative cis-regulatory elements (CREs) that may play a role in coordinating these patterns. The database is accessible from the address http://www.aegep.bio.uci.edu.

conclusionsThe combination of gene expression, function and sequence data coupled with integrated sequence analysis tools allows for identification of expression patterns and streamlines the development of CRE predictions and experiments to assess how patterns of expression are coordinated at the molecular level.

Identifiers

PMID20920356
PMCPMC2958886

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.