ArticleItalian journal of pediatrics2010
Relationship between severe obesity and gut inflammation in children: what's next?
Article in Italian journal of pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Suboptimal vitamin D status and overweight/obesity are associated with gut integrity and inflammation in minority children and adolescents: A cross-sectional analysis from the MetA-bone trial.Nutrition research (New York, N.Y.) · 2025Trial
- Can fecal calprotectin be used as a biomarker of non-alcoholic fatty liver disease in obese adolescents?BMC pediatrics · 2024Trial
- Biomarkers and Mechanisms in the Early Assessment of Childhood Obesity from a Multidisciplinary Perspective-A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Enterocyte superoxide dismutase 2 deletion drives obesity.iScience · 2022Article
- What can we learn from β-cell failure biomarker application in diabetes in childhood? A systematic review.World journal of diabetes · 2021Article
- Faecal biomarkers in type 1 diabetes with and without diabetic nephropathy.Scientific reports · 2021Article
- Association of clinical characteristics and lifestyle factors with fecal S100/calgranulin concentrations in healthy dogs.Veterinary medicine and science · 2021Article
- A Combination of Glucagon-Like Peptide-1 Receptor Agonist and Dietary Intervention Could Be a Promising Approach for Obesity Treatment.Frontiers in endocrinology · 2021Review
- Review
- Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Attenuate Pro-inflammatory Small Intestinal Cytokine Signatures.Obesity surgery · 2019Article
- A Study of Fecal Calprotectin in Obese Children and Adults.Journal of obesity & metabolic syndrome · 2018Article
- Stool Immune Profiles Evince Gastrointestinal Inflammation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2018Article
- Faecal calprotectin: factors affecting levels and its potential role as a surrogate marker for risk of development of Crohn's Disease.BMC gastroenterology · 2016Review
- High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22.Scientific reports · 2016Article
- The Effect of High-Fat Diet-Induced Pathophysiological Changes in the Gut on Obesity: What Should be the Ideal Treatment?Clinical and translational gastroenterology · 2013Article
- Effect of a High Protein Weight Loss Diet on Weight, High-Sensitivity C-Reactive Protein, and Cardiovascular Risk among Overweight and Obese Women: A Parallel Clinical Trial.International journal of endocrinology · 2013Article
- Role of intestinal inflammation as an early event in obesity and insulin resistance.Current opinion in clinical nutrition and metabolic care · 2011Review
- Increased levels of calprotectin in obesity are related to macrophage content: impact on inflammation and effect of weight loss.Molecular medicine (Cambridge, Mass.) · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreliminary evidence suggests an association between obesity and gut inflammation.
aimsTo evaluate the frequency of glucose abnormalities and their correlation with systemic and intestinal inflammation in severely obese children. PATIENTS AND
methodsThirty-four children (25 males; median age 10.8 ± 3.4 yrs) with severe obesity (BMI >95%) were screened for diabetes with oral glucose tolerance test (OGTT), systemic inflammation with C-reactive protein (CRP) and gut inflammation with rectal nitric oxide (NO) and faecal calprotectin.
resultsBMI ranged from 23 to 44 kg/m2, and BMI z-score between 2.08 e 4.93 (median 2.69 ± 0.53). Glucose abnormalities were documented in 71% of patients: type 2 diabetes in 29%, impaired fasting glucose (IFG) in 58%, and impaired glucose tolerance (IGT) in 37.5%. Thirty-one patients (91%) were hyperinsulinemic. CRP was increased in 73.5% with a correlation between BMI z-score and CRP (p 0.03). Faecal calprotectin was increased in 47% patients (mean 77 ± 68), and in 50% of children with abnormal glucose metabolism (mean 76 ± 68 μg/g), with a correlation with increasing BMI z-score. NO was pathological in 88%, and in 87.5% of glucose impairment (mean 6.8 ± 5 μM).
conclusionsIn this study, the prevalence of glucose abnormalities in obese children is higher than in other series; furthermore, a correlation is present between markers of systemic and intestinal inflammation and glucose abnormalities.
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