ArticleBMC gastroenterology2010
Helicobacter pylori infection and gastroduodenal diseases in Vietnam: a cross-sectional, hospital-based study.
Article in BMC gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Prevalence and patterns of peptic ulcer disease in Africa: a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- CagA toxin and risk of Helicobacter pylori-infected gastric phenotype: A meta-analysis of observational studies.PloS one · 2024Pooled it
- Role of Helicobacter pylori cagA EPIYA motif and vacA genotypes for the development of gastrointestinal diseases in Southeast Asian countries: a meta-analysis.BMC infectious diseases · 2012Pooled it
- Value of a new stick-type rapid urine test for the diagnosis of Helicobacter pylori infection in the Vietnamese population.World journal of gastroenterology · 2014Trial
- Strengthening upper gastrointestinal endoscopy service in primary healthcare settings in low- and middle-income countries: Proposals from an implementation study in Vietnam.Global health & medicine · 2026Review
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- Comparison ofJGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Helicobacter pylori cagA, vacA, and iceA genotypes and clinical outcomes: a cross-sectional study in central Vietnam.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Diagnostic Accuracy of Narrow-Band Imaging in Predicting Helicobacter pylori Gastritis in Patients With Dyspepsia.Cureus · 2024Article
- Prophylactic immunization to Helicobacter pylori infection using spore vectored vaccines.Helicobacter · 2023Article
- Comparative genomics of two Vietnamese Helicobacter pylori strains, CHC155 from a non-cardia gastric cancer patient and VN1291 from a duodenal ulcer patient.Scientific reports · 2023Article
- Chinese integrated guideline on the management of gastric precancerous conditions and lesions.Chinese medicine · 2022Review
- Serum pepsinogen: A potential non-invasive screening method for moderate and severe atrophic gastritis among an asian population.Annals of medicine and surgery (2012) · 2022Article
- Emergence of amoxicillin resistance and identification of novel mutations of the pbp1A gene in Helicobacter pylori in Vietnam.BMC microbiology · 2022Article
- Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Article
- Vietnam Association of Gastroenterology (VNAGE) consensus on the management ofFrontiers in medicine · 2022Review
- The endemic Helicobacter pylori population in Southern Vietnam has both South East Asian and European origins.Gut pathogens · 2021Article
- Overview ofGut and liver · 2021Review
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe rate of H. pylori infection in Vietnam is reportedly high, but the spectrum of H. pylori-associated gastroduodenal diseases has not been systematically investigated. Moreover, despite the similarities of ethnicity and diet, the age-standardized incidence rate of gastric cancer in the northern city of Hanoi is higher than that in the southern city of Ho Chi Minh, but the reason for this phenomenon is unknown. The virulence of Vietnamese H. pylori has also not been investigated in detail.
methodsIndividuals undergoing esophagogastroduodenoscopy were randomly recruited. H. pylori infection status was determined based on the combined results of culture, histology, immunohistochemistry, rapid urine test and serum ELISA. Peptic ulcer (PU) and gastroesophageal reflux disease was diagnosed by endoscopy, and chronic gastritis was determined histologically. H. pylori virulence factors were investigated by PCR and sequencing.
resultsAmong the examined patients, 65.6% were infected with H. pylori. The prevalence of infection was significantly higher in those over 40 years of age than in those aged ≤40. Chronic gastritis was present in all H. pylori-infected individuals, 83.1% of whom had active gastritis, and 85.3% and 14.7% had atrophy and intestinal metaplasia, respectively. PU was present in 21% of infected patients, whereas its incidence was very low in non-infected individuals. The prevalence of PU was significantly higher in Hanoi than in Ho Chi Minh. The prevalence of vacA m1, which has been identified as an independent risk factor for PU in Vietnam, was significantly higher among H. pylori isolates from Hanoi than among those from Ho Chi Minh.
conclusionsH. pylori infection is common in Vietnam and is strongly associated with PU, active gastritis, atrophy and intestinal metaplasia. vacA m1 is associated with an increased risk for PU and might contribute to the difference in the prevalence of PU and gastric cancer between Hanoi and Ho Chi Minh.
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