ArticleGenome biology2010
Novel venom gene discovery in the platypus.
Article in Genome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 70 citations in OpenAlex.
- Insights into platypus crural gland transcriptomics - venom and beyond.BMC genomics · 2025Article
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- A new, widespread venomous mammal species: hemolytic activity of Sorex araneus venom is similar to that of Neomys fodiens venom.Zoological letters · 2022Article
- Shrew's venom quickly causes circulation disorder, analgesia and hypokinesia.Cellular and molecular life sciences : CMLS · 2022Article
- Molecular Evolution of Ecological Specialisation: Genomic Insights from the Diversification of Murine Rodents.Genome biology and evolution · 2021Article
- Article
- Review
- Review
- Adaptive venom evolution and toxicity in octopods is driven by extensive novel gene formation, expansion, and loss.GigaScience · 2020Article
- Transcriptomic Analysis of Four Cerianthid (Cnidaria, Ceriantharia) Venoms.Marine drugs · 2020Article
- Venomics and Cellular Toxicity of Thai Pit Vipers (Trimeresurus macrops and T. hageni).Toxins · 2020Article
- Integrating natural history collections and comparative genomics to study the genetic architecture of convergent evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- The platypus: evolutionary history, biology, and an uncertain future.Journal of mammalogy · 2019Article
- Alternative Transcription at Venom Genes and Its Role as a Complementary Mechanism for the Generation of Venom Complexity in the Common House Spider.Frontiers in ecology and evolution · 2019Article
- Are Fireworms Venomous? Evidence for the Convergent Evolution of Toxin Homologs in Three Species of Fireworms (Annelida, Amphinomidae).Genome biology and evolution · 2018Article
- Venomics of Remipede Crustaceans Reveals Novel Peptide Diversity and Illuminates the Venom's Biological Role.Toxins · 2017Article
- Multiomics analysis of the giant triton snail salivary gland, a crown-of-thorns starfish predator.Scientific reports · 2017Article
- Cabinet of Curiosities: Venom Systems and Their Ecological Function in Mammals, with a Focus on Primates.Toxins · 2015Review
- Gene structure, regulatory control, and evolution of black widow venom latrotoxins.FEBS letters · 2014Article
- A Polychaete's powerful punch: venom gland transcriptomics of Glycera reveals a complex cocktail of toxin homologs.Genome biology and evolution · 2014Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo date, few peptides in the complex mixture of platypus venom have been identified and sequenced, in part due to the limited amounts of platypus venom available to study. We have constructed and sequenced a cDNA library from an active platypus venom gland to identify the remaining components.
resultsWe identified 83 novel putative platypus venom genes from 13 toxin families, which are homologous to known toxins from a wide range of vertebrates (fish, reptiles, insectivores) and invertebrates (spiders, sea anemones, starfish). A number of these are expressed in tissues other than the venom gland, and at least three of these families (those with homology to toxins from distant invertebrates) may play non-toxin roles. Thus, further functional testing is required to confirm venom activity. However, the presence of similar putative toxins in such widely divergent species provides further evidence for the hypothesis that there are certain protein families that are selected preferentially during evolution to become venom peptides. We have also used homology with known proteins to speculate on the contributions of each venom component to the symptoms of platypus envenomation.
conclusionsThis study represents a step towards fully characterizing the first mammal venom transcriptome. We have found similarities between putative platypus toxins and those of a number of unrelated species, providing insight into the evolution of mammalian venom.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.