Evidence map›Paper›PMID 20920189›Full record

ArticleRespiratory research2010

Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression.

Shyamala Ganesan, Andrea N Faris, Adam T Comstock, Sangbrita S Chattoraj, Asamanja Chattoraj, John R Burgess, Jeffrey L Curtis, Fernando J Martinez, Suzanna Zick, Marc B Hershenson and 1 more

3 registry-linked trialsOpen access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 74 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01708278 phase1completednot on this mapstarted 2014, after this paper: background citation

Phase I Study to Determine the Safety of Quercetin in COPD Patients

TypeinterventionalSponsorUniversity of MichiganRan2014 to 2015Enrolled9ConditionsChronic Obstructive Pulmonary DiseaseArmsQuercetin, Placebo - sugar chew
NCT03989271 phase1 / phase2unknown statusnot on this mapstarted 2019, after this paper: background citation

Impact of Quercetin on Inflammatory and Oxidative Stress Markers in COPD

TypeinterventionalSponsorTemple UniversityRan2019 to 2025Enrolled29ConditionsChronic Obstructive Pulmonary DiseaseArmsQuercetin
NCT06003270 phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

Effects of Quercetin on the Oxidative Stress and Inflammatory Markers in COPD Phase II

TypeinterventionalSponsorTemple UniversityRan2023 to 2025Enrolled30ConditionsChronic Obstructive Pulmonary Disease, Emphysema, Chronic Bronchitis With Airway ObstructionArmsQuercetin 1000 mg, Quercetin 500 MG, Placebo
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 152 citations in OpenAlex.

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  14. Cellular senescence in adult pulmonary hypertension: current state and future challenges.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
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  17. Article
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  19. Natural Products for the Management of Asthma and COPD.Handbook of experimental pharmacology · 2025
    Review
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Shyamala GanesanDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109, USA.
Andrea N Faris
Adam T Comstock
Sangbrita S Chattoraj
Asamanja Chattoraj
John R Burgess
Jeffrey L Curtis
Fernando J Martinez
Suzanna Zick
Marc B Hershenson
Uma S Sajjan
University of Michigan–Ann Arbor · USPurdue University West Lafayette · US

Funding

Quercetin and Innate Immune Responses in COPDR01AT004793 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SAJJAN, UMADEVI SIVANAPPA · 2008 to 2011
$1.4M
NCCIH NIH HHS AT004793NCCIH NIH HHS R01 AT004793
6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis, emphysema and irreversible airflow limitation. These changes are thought to be due to oxidative stress and an imbalance of proteases and antiproteases. Quercetin, a plant flavonoid, is a potent antioxidant and anti-inflammatory agent. We hypothesized that quercetin reduces lung inflammation and improves lung function in elastase/lipopolysaccharide (LPS)-exposed mice which show typical features of COPD, including airways inflammation, goblet cell metaplasia, and emphysema.

methodsMice treated with elastase and LPS once a week for 4 weeks were subsequently administered 0.5 mg of quercetin dihydrate or 50% propylene glycol (vehicle) by gavage for 10 days. Lungs were examined for elastance, oxidative stress, inflammation, and matrix metalloproteinase (MMP) activity. Effects of quercetin on MMP transcription and activity were examined in LPS-exposed murine macrophages.

resultsQuercetin-treated, elastase/LPS-exposed mice showed improved elastic recoil and decreased alveolar chord length compared to vehicle-treated controls. Quercetin-treated mice showed decreased levels of thiobarbituric acid reactive substances, a measure of lipid peroxidation caused by oxidative stress. Quercetin also reduced lung inflammation, goblet cell metaplasia, and mRNA expression of pro-inflammatory cytokines and muc5AC. Quercetin treatment decreased the expression and activity of MMP9 and MMP12 in vivo and in vitro, while increasing expression of the histone deacetylase Sirt-1 and suppressing MMP promoter H4 acetylation. Finally, co-treatment with the Sirt-1 inhibitor sirtinol blocked the effects of quercetin on the lung phenotype.

conclusionsQuercetin prevents progression of emphysema in elastase/LPS-treated mice by reducing oxidative stress, lung inflammation and expression of MMP9 and MMP12.

Indexed as

AnimalsCells, CulturedDisease ProgressionGene Expression Regulation, EnzymologicLipopolysaccharidesMatrix Metalloproteinase InhibitorsMatrix MetalloproteinasesMiceMice, Inbred C57BLPancreatic ElastasePulmonary Disease, Chronic ObstructiveQuercetinSwineLipopolysaccharidesMatrix Metalloproteinase InhibitorsMatrix MetalloproteinasesPancreatic ElastaseQuercetin

Identifiers

PMID20920189
PMCPMC2954923
OpenAlexW2093117593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.