ReviewWiley interdisciplinary reviews. Systems biology and medicine
Systems analysis of salivary gland development and disease.
Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Unveiling critical signaling pathways in the murine salivary gland and the role of midkine.iScience · 2026Article
- FGF signaling regulates salivary gland branching morphogenesis by modulating cell adhesion.Development (Cambridge, England) · 2023Article
- Article
- Cocktail Formula and Application Prospects for Oral and Maxillofacial Organoids.Tissue engineering and regenerative medicine · 2022Review
- Engineering the mode of morphogenetic signal presentation to promote branching from salivary gland spheroids in 3D hydrogels.Acta biomaterialia · 2020Article
- Expression patterns of genes critical for SHH, BMP, and FGF pathways during the lumen formation of human salivary glands.Journal of molecular histology · 2019Article
- Genetic and scRNA-seq Analysis Reveals Distinct Cell Populations that Contribute to Salivary Gland Development and Maintenance.Scientific reports · 2018Article
- Genome-wide uniparental diploidy of all paternal chromosomes in an 11-year-old girl with deafness and without malignancy.Journal of human genetics · 2018Article
- Patterned cell and matrix dynamics in branching morphogenesis.The Journal of cell biology · 2017Review
- RNA-seq based transcriptomic map reveals new insights into mouse salivary gland development and maturation.BMC genomics · 2016Article
- Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands.Immunity · 2016Article
- The effect of valproic acid on the phenotypic plasticity of salivary gland cells.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2013Article
- The control of branching morphogenesis.Open biology · 2013Review
- Region-specific epithelial cell dynamics during branching morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Cell-based multi-parametric model of cleft progression during submandibular salivary gland branching morphogenesis.PLoS computational biology · 2013Article
- Inhibitory morphogens and monopodial branching of the embryonic chicken lung.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- The regulation of focal adhesion complex formation and salivary gland epithelial cell organization by nanofibrous PLGA scaffolds.Biomaterials · 2012Article
- Viral gene transfer to developing mouse salivary glands.Journal of dental research · 2012Article
- Article
- Dynamics of salivary gland morphogenesis.Journal of dental research · 2011Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
Branching morphogenesis is a crucial developmental process in which vertebrate organs generate extensive epithelial surface area while retaining a compact size. In the vertebrate submandibular salivary gland, branching morphogenesis is crucial for the generation of the large surface area necessary to produce sufficient saliva. However, in many salivary gland diseases, saliva-producing acinar cells are destroyed, resulting in dry mouth and secondary health conditions. Systems-based approaches can provide insights into understanding salivary gland development, function, and disease. The traditional approach to understanding these processes is the identification of molecular signals using reductionist approaches; we review current progress with such methods in understanding salivary gland development. Taking a more global approach, multiple groups are currently profiling the transcriptome, the proteome, and other 'omes' in both developing mouse tissues and in human patient samples. Computational methods have been successful in deciphering large data sets, and mathematical models are starting to make predictions regarding the contribution of molecules to the physical processes of morphogenesis and cellular function. A challenge for the future will be to establish comprehensive, publicly accessible salivary gland databases spanning the full range of genes and proteins; plans are underway to provide these resources to researchers in centralized repositories. The greatest challenge for the future will be to develop realistic models that integrate multiple types of data to both describe and predict embryonic development and disease pathogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.