ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2011
(1)H-NMR-based metabolomics of tumor tissue for the metabolic characterization of rat hepatocellular carcinoma formation and metastasis.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?World journal of hepatology · 2022Review
- Metabolomics in hepatocellular carcinoma: From biomarker discovery to precision medicine.Frontiers in medical technology · 2022Review
- The Effect of Blood Contained in the Samples on the Metabolomic Profile of Mouse Brain Tissue: A Study by NMR Spectroscopy.Molecules (Basel, Switzerland) · 2021Article
- Review
- Metabolic Alterations Associated with Early-Stage Hepatocellular Carcinoma and Their Correlation with Aging and Enzymatic Activity in Patients with Viral Hepatitis-Induced Liver Cirrhosis: A Preliminary Study.Journal of clinical medicine · 2020Article
- Metabolomic Characterization of Human Model of Liver Rejection Identifies Aberrancies Linked to Cyclooxygenase (COX) and Nitric Oxide Synthase (NOS).Annals of transplantation · 2019Article
- Identification of the Potential Metabolic Pathways Involved in the Hepatic Tumorigenesis of Rat Diethylnitrosamine-Induced Hepatocellular Carcinoma viaBioMed research international · 2019Article
- Deciphering hepatocellular carcinoma through metabolomics: from biomarker discovery to therapy evaluation.Cancer management and research · 2018Review
- Article
- Nuclear Magnetic Resonance technique in tumor metabolism.Genes & diseases · 2017Review
- Plasma Lipid Profiling in a Rat Model of Hepatocellular Carcinoma: Potential Modulation Through Quinolone Administration.Journal of clinical and experimental hepatology · 2015Article
- In vivo proton MR spectroscopy of pancreatic neuroendocrine tumors in a multiple endocrine neoplasia type 1 conditional knockout mouse model.Magnetic resonance in medicine · 2015Article
- In vitro expansion of U87-MG human glioblastoma cells under hypoxic conditions affects glucose metabolism and subsequent in vivo growth.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- MRS-based Metabolomics in Cancer Research.Magnetic resonance insights · 2014Review
- The metabolomic window into hepatobiliary disease.Journal of hepatology · 2013Review
- Targeted metabolic profiling of hepatocellular carcinoma and hepatitis C using LC-MS/MS.Electrophoresis · 2013Article
- Tissue metabolomics of hepatocellular carcinoma: tumor energy metabolism and the role of transcriptomic classification.Hepatology (Baltimore, Md.) · 2013Article
- The effect of acyclic retinoid on the metabolomic profiles of hepatocytes and hepatocellular carcinoma cells.PloS one · 2013Article
- Application of NMR metabolomics to search for human disease biomarkers.Combinatorial chemistry & high throughput screening · 2012Review
- Development and preliminary testing of a translational model of hepatocellular carcinoma for MR imaging and interventional oncologic investigations.Journal of vascular and interventional radiology : JVIR · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high mortality figures for hepatocellular carcinoma (HCC) are mostly due to high recurrence and metastasis rates. However, the metabolic characteristics of HCC metastasis have not been studied extensively. In this study, we attempted to elucidate the metabolite profile of HCC formation and metastasis through proton nuclear magnetic resonance ((1)H-NMR)-based metabolomics. We first established a hepatocellular carcinoma with lung metastasis (HLM) rat model by exposure to diethylnitrosamine. Fifteen rats were then divided into three groups based on pathologic changes: HCC, HLM, and controls. The metabolite profiles of extracts from tumor tissue were obtained using high-resolution (1)H-NMR. One-way ANOVA was used to compare the metabolite levels among the three groups. Multivariate statistical analysis (specifically, unsupervised principal components analysis and supervised partial least squares discriminant analysis (PLS-DA)) were used for HCC and HLM metabolite profiling and data interpretation. PLS-DA models could discern HCC or HLM rats from normal (control) rats. Tumor tissue from HLM showed changes in glucose, lactate, choline, lipids, and some amino acids such as glycine. The results of this pilot study suggest that alterations in glycolysis and the metabolism of glycine and choline occur during HCC invasion and metastasis.
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