ArticleHistochemistry and cell biology2010
Comprehensive characterization of expression patterns of protein 4.1 family members in mouse adrenal gland: implications for functions.
Article in Histochemistry and cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Tumor Suppressor 4.1N/Frontiers in genetics · 2022Article
- Selective effects of protein 4.1N deficiency on neuroendocrine and reproductive systems.Scientific reports · 2020Article
- [Construction of a stable 4.1R gene knockout cell model in RAW264.7 cells using CRISPR/Cas9 technique].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Proteomic and phosphoproteomic analysis of renal cortex in a salt-load rat model of advanced kidney damage.Scientific reports · 2016Article
- 4.1N is involved in a flotillin-1/β-catenin/Wnt pathway and suppresses cell proliferation and migration in non-small cell lung cancer cell lines.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Protein 4.1G Regulates Cell Adhesion, Spreading, and Migration of Mouse Embryonic Fibroblasts through the β1 Integrin Pathway.The Journal of biological chemistry · 2016Article
- DAL-1 attenuates epithelial-to mesenchymal transition in lung cancer.Journal of experimental & clinical cancer research : CR · 2015Article
- Tumor suppressor role of protein 4.1B/DAL-1.Cellular and molecular life sciences : CMLS · 2014Review
- Comprehensive characterization of protein 4.1 expression in epithelium of large intestine.Histochemistry and cell biology · 2014Article
- Interaction of 4.1G and cGMP-gated channels in rod photoreceptor outer segments.Journal of cell science · 2013Article
- Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility.Molecular and cellular biology · 2011Article
- Histochemistry and cell biology: the annual review 2010.Histochemistry and cell biology · 2011Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
The members of the protein 4.1 family, 4.1R, 4.1G, 4.1N, and 4.1B, are encoded by four genes, all of which undergo complex alternative splicing. It is well established that 4.1R, the prototypical member of the family, serves as an adapter that links the spectrin-actin based cytoskeleton to the plasma membrane in red cells. It is required for mechanical resilience of the membrane, and it ensures the cell surface accumulation of selected membrane proteins. However, the function of 4.1 proteins outside erythrocytes remains under-explored, especially in endocrine tissues. Transcripts of all 4.1 homologs have previously been documented to be abundantly expressed in adrenal gland. In order to begin to decipher the function of 4.1 proteins in adrenal gland, we performed a detailed characterization of the expression pattern of various 4.1 proteins and their cellular localization. We show that 4.1R (~80 and ~135 kDa) splice forms are expressed on the membrane of all cells, while a ~160 kDa 4.1G splice form is distributed in the cytoplasm and the membrane of zona glomerulosa and of medullary cells. Two 4.1N splice forms, ~135 and ~95 kDa, are present in the peri-nuclear region of both zona glomerulosa and medullary cells, while a single ~130 kDa 4.1B splice form, is detected in all layers of adrenal gland in both the cytoplasm and the membrane. The characterization of distinct splice forms of various 4.1 proteins with diverse cellular and sub-cellular localization indicates multiple functions for this family of proteins in endocrine functions of adrenal gland.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.