Trial reportNeurocritical care2011
Short-term outcome prediction by electroencephalographic features in children treated with therapeutic hypothermia after cardiac arrest.
Trial report in Neurocritical care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- 2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 8. Pediatric advanced life support.Clinical and experimental emergency medicine · 2026Guideline
- Value and mechanisms of EEG reactivity in the prognosis of patients with impaired consciousness: a systematic review.Critical care (London, England) · 2018Pooled it
- Singapore Paediatric Resuscitation Guidelines 2016.Singapore medical journal · 2017Guideline
- Part 12: Pediatric Advanced Life Support: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.Circulation · 2015Guideline
- Hypothermia for neuroprotection in children after cardiopulmonary arrest.The Cochrane database of systematic reviews · 2013Pooled it
- Association of EEG characteristics with outcomes following pediatric ICU cardiac arrest: A secondary analysis of the ICU-RESUScitation trial.Resuscitation · 2024Trial
- Association of EEG Response to Hypertonic Saline and Neurologic Outcomes in Pediatric Acute Brain Injury.Neurocritical care · 2026Article
- Electroencephalographic and clinical predictors of favorable neurologic outcomes in pediatric cardiac arrest survivors.Scientific reports · 2025Article
- Article
- Neuromonitoring after Pediatric Cardiac Arrest: Cerebral Physiology and Injury Stratification.Neurocritical care · 2024Review
- Review
- Amplitude-Integrated EEG Monitoring in Pediatric Intensive Care: Prognostic Value in Meningitis before One Year of Age.Children (Basel, Switzerland) · 2022Article
- Multimodal monitoring including early EEG improves stratification of brain injury severity after pediatric cardiac arrest.Resuscitation · 2021Observational
- Neurological Prognostication in Children After Cardiac Arrest.Pediatric neurology · 2020Review
- How can neurological outcomes be predicted in comatose pediatric patients after out-of-hospital cardiac arrest?Clinical and experimental pediatrics · 2020Article
- Prognostic value of the delta neutrophil index in pediatric cardiac arrest.Scientific reports · 2020Article
- Early EEG Features for Outcome Prediction After Cardiac Arrest in Children.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2019Observational
- Observational
- Stability of Early EEG Background Patterns After Pediatric Cardiac Arrest.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2018Observational
- EEG Factors After Pediatric Cardiac Arrest.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundElectroencephalographic (EEG) features may provide objective data regarding prognosis in children resuscitated from cardiac arrest (CA), but therapeutic hypothermia (TH) may impact its predictive value. We aimed to determine whether specific EEG features were predictive of short-term outcome in children treated with TH after CA, both during hypothermia and after return to normothermia.
methodsThirty-five children managed with a standard clinical TH algorithm after CA were prospectively enrolled. EEG recordings were scored in a standardized manner and categorized. EEG category 1 consisted of continuous and reactive tracings. EEG category 2 consisted of continuous but unreactive tracings. EEG category 3 included those with any degree of discontinuity, burst suppression, or lack of cerebral activity. The primary outcome was unfavorable short-term outcome defined as Pediatric Cerebral Performance Category score of 4-6 (severe disability, vegetative, death) at hospital discharge. Univariate analyses of the association between EEG category and outcome was performed using logistic regression.
resultsFor tracings obtained during hypothermia, patients with EEGs in categories 2 or 3 were far more likely to have poor outcome than those in category 1 (OR 10.7, P = 0.023 and OR 35, P = 0.004, respectively). Similarly, for tracings obtained during normothermia, patients with EEGs in categories 2 or 3 were far more likely to have poor outcomes than those in category 1 (OR 27, P = 0.006 and OR 18, P = 0.02, respectively).
conclusionsA simple EEG classification scheme has predictive value for short-term outcome in children undergoing TH after CA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.