ArticleCellscience2010
FGF ligands emerge as potential specifiers of synaptic identity.
Article in Cellscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- FGF binding proteins (FGFBPs): Modulators of FGF signaling in the developing, adult, and stressed nervous system.Biochimica et biophysica acta. Molecular basis of disease · 2018Review
- Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis.Development (Cambridge, England) · 2015Article
- Implication of fibroblast growth factors in epileptogenesis-associated circuit rearrangements.Frontiers in cellular neuroscience · 2013Article
- Signaling in cell differentiation and morphogenesis.Cold Spring Harbor perspectives in biology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution.
Funding
Abstract
The central nervous system (CNS) consists of trillions of interconnected neurons. The specialised regions of intercellular contact between neurons where information, usually in chemical form, is transmitted are called synapses. The last decade has seen an unprecedented advance in our understanding of the molecular nature, formation and maintenance of synapses. A major question that remains is how synaptic identity is established to ensure the coordinated recruitment of the correct synaptic components on both sides of the synapse so that the neurotransmitter accumulating on the presynaptic side is matched with its cognate receptor on the postsynaptic membrane. Until recently, Fibroblast Growth Factors (FGFs) have been thought of as general regulators of synaptic aptitude through their ability to increase the expression of synaptic proteins or promote neurite branching. A recent study shows that the decision to form an excitatory vs. inhibitory synapse may to a large extent be determined by the identity of the FGF ligand present at the postsynaptic membrane. This observation establishes FGFs as key target-derived cues that are involved in determining synaptic identity.
Identifiers
20890457PMC2948530W95787911What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.