ArticleHaematologica reports2006
Thymic and extrathymic contributions to T helper cell function in murine neonates.
Article in Haematologica reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Building a T cell compartment: how immune cell development shapes function.Nature reviews. Immunology · 2020Review
- Cerebellar fastigial nuclear glutamatergic neurons regulate immune function via hypothalamic and sympathetic pathways.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2015Article
- The murine Th2 locus undergoes epigenetic modification in the thymus during fetal and postnatal ontogeny.PloS one · 2013Article
- Article
- Heterogeneity in the CD4 T Cell Compartment and the Variability of Neonatal Immune Responsiveness.Current immunology reviews · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Murine neonatal CD4+ responses are often biased to Th2 function. There is increasing evidence that this phenomenon may be regulated both at the level of the thymus and the peripheral lymphoid compartment. In particular, residual fetal influence on the neonatal thymus may lead to an imprinting of developing T cells that is maintained in CD4+ cells when they emigrate to peripheral organs. Such imprinting may involve epigenetic modification of the Th2 cytokine gene locus and acquisition of the capacity to undergo rapid cell cycling. These properties, coupled with the homeostatic proliferation occurring in the peripheral tissues of neonates, shape a CD4+ population with the capacity for enhanced Th2 responsiveness.
Identifiers
20890454PMC2948465What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.