ArticlePLoS currents2010
Drosophila Models of Huntington's Disease exhibit sleep abnormalities.
Article in PLoS currents, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- CREB promotes starvation-induced sleep loss by regulating octopamine production in Drosophila.Biology open · 2026Article
- Genipin Alleviates Sleep Deficiencies Caused by α-Synuclein Toxicity in amicroPublication biology · 2026Article
- The CRTC-CREB axis functions as a transcriptional sensor to protect against proteotoxic stress in Drosophila.Cell death & disease · 2022Article
- Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons.PLoS genetics · 2019Article
- Mutant huntingtin disturbs circadian clock gene expression and sleep patterns in Drosophila.Scientific reports · 2019Article
- Early-onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.Human molecular genetics · 2016Article
- Consequences of Circadian Disruption on Neurologic Health.Sleep medicine clinics · 2015Review
- Circadian dysfunction in response to in vivo treatment with the mitochondrial toxin 3-nitropropionic acid.ASN neuro · 2014Article
- Choosing an animal model for the study of Huntington's disease.Nature reviews. Neuroscience · 2013Review
- Modeling the genetic basis for human sleep disorders in Drosophila.Communicative & integrative biology · 2013Article
- Epigenetic regulation of axonal growth of Drosophila pacemaker cells by histone acetyltransferase tip60 controls sleep.Genetics · 2012Article
- Factors that Differentially Affect Daytime and Nighttime Sleep in Drosophila melanogaster.Frontiers in neurology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The complex pathology of neurodegenerative diseases presents a challenge to researchers who model the disease, and clinicians who treat patients. The identification of early, perhaps even prodromal, biomarkers is important for developing strategies to ameliorate disease progression. Sleep disturbances are a clinical feature of Huntington's disease (HD) as well as a part of normal aging. Whether sleep dysfunctions in HD patients are epiphenomenal or central to the neurodegenerative disease process is unclear. We show that sleep fragmentation is shared among Drosophila transgenic models that express mutant forms of huntingtin (mHtt), and flies with RNAi-mediated knockdown of the endogenous gene (dhtt). Our data suggest that sleep disturbances in HD may represent loss of function in the endogenous dhtt gene and that sleep perturbations in Drosophila HD models present an opportunity for screening therapeutic interventions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.