ArticleOncogene2011
The normal mammary microenvironment suppresses the tumorigenic phenotype of mouse mammary tumor virus-neu-transformed mammary tumor cells.
Article in Oncogene, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 85 citations in OpenAlex.
- Dying cells as architects of the stem cell niche: a conserved mechanism driving tissue regeneration and tumor therapy resistance.Cell communication and signaling : CCS · 2026Review
- Intercellular mitochondrial transfer contributes to microenvironmental redirection of cancer cell fate.The FEBS journal · 2025Article
- Mechanisms of Regulation of Cell Fate in Breast Development and Cancer.Advances in experimental medicine and biology · 2025Review
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- Eta polycaprolactone (ε-PCL) implants appear to cause a partial differentiation of breast cancer lung metastasis in a murine model.BMC cancer · 2023Article
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- Combined 3D bioprinting and tissue-specific ECM system reveals the influence of brain matrix on stem cell differentiation.Frontiers in cell and developmental biology · 2023Article
- Immunity beyond cancer cells: perspective from tumor tissue.Trends in cancer · 2021Review
- ΔN63 suppresses the ability of pregnancy-identified mammary epithelial cells (PIMECs) to drive HER2-positive breast cancer.Cell death & disease · 2021Article
- A Similar Speciation Process Relying on Cellular Stochasticity in Microbial and Cancer Cell Populations.iScience · 2020Review
- Cancer associated fibroblast: Mediators of tumorigenesis.Matrix biology : journal of the International Society for Matrix Biology · 2020Review
- Induction of phenotypic changes in HER2-postive breast cancer cellsOncotarget · 2020Article
- Redirecting Normal and Cancer Stem Cells to a Mammary Epithelial Cell Fate.Journal of mammary gland biology and neoplasia · 2019Review
- 3D bioprinted mammary organoids and tumoroids in human mammary derived ECM hydrogels.Acta biomaterialia · 2019Article
- A 3D bioprinter platform for mechanistic analysis of tumoroids and chimeric mammary organoids.Scientific reports · 2019Article
- Intraductal Adaptation of the 4T1 Mouse Model of Breast Cancer Reveals Effects of the Epithelial Microenvironment on Tumor Progression and Metastasis.Anticancer research · 2019Article
- Amphiregulin regulates proliferation and migration of HER2-positive breast cancer cells.Cellular oncology (Dordrecht, Netherlands) · 2018Article
- An Integrative Approach Toward Biology, Organisms, and Cancer.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Article
- Mammary extracellular matrix directs differentiation of testicular and embryonic stem cells to form functional mammary glands in vivo.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The microenvironment of the mammary gland has been shown to exert a deterministic control over cells from different normal organs during murine mammary gland regeneration in transplantation studies. When mouse mammary tumor virus (MMTV)-neu-induced tumor cells were mixed with normal mammary epithelial cells (MECs) in a dilution series and inoculated into epithelium-free mammary fat pads, they were redirected to non-carcinogenic cell fates by interaction with untransformed MECs during regenerative growth. In the presence of non-transformed MECs (50:1), tumor cells interacted with MECs to generate functional chimeric outgrowths. When injected alone, tumor cells invariably produced tumors. Here, the normal microenvironment redirects MMTV-neu-transformed tumorigenic cells to participate in the regeneration of a normal, functional mammary gland. In addition, the redirected tumor cells show the capacity to differentiate into normal mammary cell types, including luminal, myoepithelial and secretory. The results indicate that signals emanating from a normal mammary microenvironment, comprised of stromal, epithelial and host-mediated signals, combine to suppress the cancer phenotype during glandular regeneration. Clarification of these signals offers improved therapeutic possibilities for the control of mammary cancer growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.