ArticleNature neuroscience2010
Functional imaging of hippocampal place cells at cellular resolution during virtual navigation.
Article in Nature neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 465 papers.
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Who cites it
465 citing papers in PubMed, 932 citations in OpenAlex.
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- Voltage imaging of CA1 pyramidal cells and SST+ interneurons reveals stability and plasticity mechanisms of spatial firing.Nature communications · 2026Article
- Visual uncertainty and task demands shape active sensing strategies in mice.bioRxiv : the preprint server for biology · 2026Article
- Transformations of the spatial activity manifold convey aversive information in CA3.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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- A Deterministically Synchronized Widefield Imaging and Virtual Reality Platform for Multimodal Brain-Behavior Recording.bioRxiv : the preprint server for biology · 2026Article
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- The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations.Nature neuroscience · 2026Article
- Hippocampal conditioning code dominates and disrupts the place code.bioRxiv : the preprint server for biology · 2026Article
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- Single-Cell Perturbations Reveal Selective Modulation of Causal Connectivity During Decision-Making.bioRxiv : the preprint server for biology · 2026Article
- Probabilistic Perceptual Decisions during Navigation Are Driven by a Small Subpopulation of Neurons in a Single Cortical Column of the Primary Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
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- Place cells in CA1 lack topographical organization of firing locations.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Unconstrained Plasticity Disrupts Memory Consolidation in a Mouse Model of Rett Syndrome.bioRxiv : the preprint server for biology · 2026Article
- An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement.bioRxiv : the preprint server for biology · 2026Article
- Fast dendritic excitations primarily mediate back-propagation in CA1 pyramidal neurons during behavior.bioRxiv : the preprint server for biology · 2026Article
405 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Spatial navigation is often used as a behavioral task in studies of the neuronal circuits that underlie cognition, learning and memory in rodents. The combination of in vivo microscopy with genetically encoded indicators has provided an important new tool for studying neuronal circuits, but has been technically difficult to apply during navigation. Here we describe methods for imaging the activity of neurons in the CA1 region of the hippocampus with subcellular resolution in behaving mice. Neurons that expressed the genetically encoded calcium indicator GCaMP3 were imaged through a chronic hippocampal window. Head-restrained mice performed spatial behaviors in a setup combining a virtual reality system and a custom-built two-photon microscope. We optically identified populations of place cells and determined the correlation between the location of their place fields in the virtual environment and their anatomical location in the local circuit. The combination of virtual reality and high-resolution functional imaging should allow a new generation of studies to investigate neuronal circuit dynamics during behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.