ArticleNeuroreport2010
Glucose increases activity and Ca2+ in insulin-producing cells of adult Drosophila.
Article in Neuroreport, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 79 citations in OpenAlex.
- Sex-specific metabolic regulation by the Drosophila RNA-binding protein Nab2.bioRxiv : the preprint server for biology · 2026Article
- Article
- Insulin/insulin-like growth factor signaling pathway promotes higher fat storage inbioRxiv : the preprint server for biology · 2025Article
- Article
- A nutrient responsive lipase mediates gut-brain communication to regulate insulin secretion in Drosophila.Nature communications · 2024Article
- A comprehensiveFrontiers in pharmacology · 2024Review
- Insulin signaling in development.Development (Cambridge, England) · 2023Article
- Contributive Role of Hyperglycemia and Hypoglycemia Towards the Development of Alzheimer's Disease.Molecular neurobiology · 2022Review
- Of flies, mice and neural control of food intake: lessons to learn from both models.Current opinion in neurobiology · 2022Review
- Nutrient Sensing via Gut inInternational journal of molecular sciences · 2022Review
- Endocrine Regulation of Lifespan in Insect Diapause.Frontiers in physiology · 2022Review
- The Genetics of Diabetes: What We Can Learn fromInternational journal of molecular sciences · 2021Review
- Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila.Cell metabolism · 2021Review
- What fuels the fly: Energy metabolism inScience advances · 2021Review
- The Glucagon-Like Adipokinetic Hormone inFrontiers in physiology · 2021Review
- Brain-Body Control of Glucose Homeostasis-Insights From Model Organisms.Frontiers in endocrinology · 2021Review
- Hormonal axes in Drosophila: regulation of hormone release and multiplicity of actions.Cell and tissue research · 2020Review
- Metabolism and growth adaptation to environmental conditions in Drosophila.Cellular and molecular life sciences : CMLS · 2020Review
- Regulation of Body Size and Growth Control.Genetics · 2020Review
- Regulation of insulin and adipokinetic hormone/glucagon production in flies.Wiley interdisciplinary reviews. Developmental biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We sought to understand the mechanisms underlying glucose sensing in Drosophila melanogaster. We found that insulin-producing cells (IPCs) of adult Drosophila respond to glucose and glibenclamide with a burst-like pattern of activity. Under controlled conditions IPCs have a resting membrane potential of -62+/-4 mV. In response to glucose or glibenclamide, IPCs generate action potentials at a threshold of -36+/-1.4 mV with an amplitude of 46+/-4 mV and width of 9.3+/-1.8 ms. Real-time Ca imaging confirms that IPCs respond to glucose and glibenclamide with increased intracellular Ca. These results provide the first detailed characterization of electrical properties of IPCs of adult Drosophila and suggest that these cells sense glucose by a mechanism similar to mammalian pancreatic β cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.