Trial reportCritical care medicine2010
Plasma adiponectin and mortality in critically ill subjects with acute respiratory failure.
Trial report in Critical care medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 67 citations in OpenAlex.
- Baseline adiponectin concentration and clinical outcomes among patients with diabetes and recent acute coronary syndrome in the EXAMINE trial.Diabetes, obesity & metabolism · 2017Trial
- The Role of Serum Adiponectin for Outcome Prediction in Patients with Dilated Cardiomyopathy and Advanced Heart Failure.BioMed research international · 2017Trial
- Harnessing adiponectin for sepsis: current knowledge, clinical insights and future therapies.Critical care (London, England) · 2025Review
- Age-stratified Association Between Plasma Adiponectin Levels and Mortality in Septic Patients.The western journal of emergency medicine · 2025Article
- Adiponectin as a predictor of mortality and readmission in patients with community-acquired pneumonia: a prospective cohort study.Frontiers in medicine · 2024Article
- Exploring the Relationship between Plasma Adiponectin, Gender, and Underlying Diseases in Severe Illness.Biomedicines · 2023Article
- Review
- Plasma as a resuscitation fluid for volume-depleted shock: Potential benefits and risks.Transfusion · 2021Review
- Vascular Endothelial Glycocalyx Plays a Role in the Obesity Paradox According to Intravital Observation.Frontiers in cardiovascular medicine · 2021Article
- Obesity: A critical risk factor in the COVID-19 pandemic.Clinical obesity · 2020Review
- The Role of Adipose Tissue and Adipokines in Sepsis: Inflammatory and Metabolic Considerations, and the Obesity Paradox.Current obesity reports · 2019Review
- Association of High Serum Adiponectin with the Risk of Malnutrition and Worse Outcome in Head Trauma Patients; a Cohort study.Archives of academic emergency medicine · 2019Article
- Visfatin Serum Levels Predict Mortality in Critically Ill Patients.Disease markers · 2018Article
- The role of adipokines as prognostic factors of one-year mortality in hip fracture patients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Genetic and epigenetic factors in the regulation of the immune response.Current opinion in pediatrics · 2016Review
- Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease.Circulation research · 2016Review
- Low Plasma Levels of Adiponectin Do Not Explain Acute Respiratory Distress Syndrome Risk: a Prospective Cohort Study of Patients with Severe Sepsis.Critical care (London, England) · 2016Article
- Circulating adipokine levels and prognostic value in septic patients.Journal of inflammation (London, England) · 2016Article
- Pre-chemotherapy risk factors for invasive fungal diseases: prospective analysis of 1,192 patients with newly diagnosed acute myeloid leukemia (SEIFEM 2010-a multicenter study).Haematologica · 2015Article
- Obesity, inflammation, and lung injury (OILI): the good.Mediators of inflammation · 2014Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objective: Adiponectin, an anti-inflammatory cytokine produced by adipose tissue, has been shown to modulate survival in animal models of critical illness. We examined the association between plasma adiponectin and clinical outcomes in critically ill patients with acute respiratory failure.
design: Secondary analysis of a single-center, randomized controlled trial.
setting: Medical intensive care unit of a university-based, tertiary medical center. PATIENTS: : One hundred seventy-five subjects with acute respiratory failure enrolled in randomized, controlled pilot trial of Early versus Delayed Enternal Nutrition (EDEN pilot study).
interventions: None. MEASUREMENTS AND MAIN
results: Adiponectin measured within 48 hrs of respiratory failure (Apn1) was inversely correlated with body mass index (r=-0.25, p=.007) and was higher in females (median, 12.6 μg/mL; interquartile range, 7.6-17.1) than males (9.45 μg/mL; 6.2-14.2; p=.02). Adiponectin increased at day 6 (Apn1: 11.4 μg/mL [6.6-15.3] vs. Apn6: 14.1 μg/mL [10.3-18.6], p<.001). This increase was significant only in survivors (Δ adiponectin in survivors: 3.9±6 μg/mL, n=80, p<.001 vs. Δ in nonsurvivors: 1.69±4.6 μg/mL, n=14, p=.19). Higher Apn1 was significantly associated with 28-day mortality (odds ratio 1.59 per 5-μg/mL increase; 95% confidence interval 1.15-2.21; p=.006). No measured demographic, clinical, or cytokine covariates, including interleukin-6, interleukin-8, interleukin-10, interleukin-1β, interleukin-12, tumor necrosis factor-α, and interferon-γ, were confounders or effect modifiers of this association between adiponectin and mortality.
conclusions: Independent of measured covariates, increased plasma adiponectin levels measured within 48 hrs of respiratory failure are associated with mortality. This finding suggests that factors derived from adipose tissue play a role in modulating the response to critical illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.