ArticleCell cycle (Georgetown, Tex.)2010
Skeletal aging and the adipocyte program: New insights from an "old" molecule.
Article in Cell cycle (Georgetown, Tex.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 58 citations in OpenAlex.
- Relationship of weight, height, and body mass index with fracture risk at different sites in postmenopausal women: the Global Longitudinal study of Osteoporosis in Women (GLOW).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Trial
- Adipose Tissue Heterogeneity: Depot-Specific Location and Functional Specialization in Obesity-Related Disease.International journal of molecular sciences · 2026Review
- The long-chain polyfluorinated alkyl substance perfluorohexane sulfonate (PFHxS) promotes bone marrow adipogenesis.Toxicology and applied pharmacology · 2024Article
- Regulatory Effect of Osteocytes on Extramedullary and Bone Marrow Adipose Tissue Development and Function.Current osteoporosis reports · 2024Review
- Effects of ligandrol as a selective androgen receptor modulator in a rat model for osteoporosis.Journal of bone and mineral metabolism · 2023Article
- Biomarkers of aging.Science China. Life sciences · 2023Review
- Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging.Current osteoporosis reports · 2023Review
- Adipocyte-activated oxidative and ER stress pathways promote tumor survival in bone via upregulation of Heme Oxygenase 1 and Survivin.Scientific reports · 2018Article
- Interferon-Gamma-Mediated Osteoimmunology.Frontiers in immunology · 2018Review
- Reflections on Cancer in the Bone Marrow: Adverse Roles of Adipocytes.Current molecular biology reports · 2017Article
- Inflammatory Changes in Bone Marrow Microenvironment Associated with Declining B Lymphopoiesis.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells.Cancer research · 2017Article
- Bone marrow adipocytes promote the Warburg phenotype in metastatic prostate tumors via HIF-1α activation.Oncotarget · 2016Article
- High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6.Oncotarget · 2016Article
- Bone marrow fat and the decline of B lymphopoiesis in rabbits.Developmental and comparative immunology · 2016Review
- Orexin Plays a Role in Growth Impediment Induced by Obstructive Sleep Breathing in Rats.Sleep · 2016Article
- Niche heterogeneity in the bone marrow.Annals of the New York Academy of Sciences · 2016Review
- Bone Marrow Adipose Tissue: A New Player in Cancer Metastasis to Bone.Frontiers in endocrinology · 2016Review
- Inhibition of B Lymphopoiesis by Adipocytes and IL-1-Producing Myeloid-Derived Suppressor Cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Marrow adipocyte-derived CXCL1 and CXCL2 contribute to osteolysis in metastatic prostate cancer.Clinical & experimental metastasis · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Aging is associated with profound changes in bone mass and body composition. Emerging evidence supports the hypothesis that alterations in mesenchymal stromal cell fate are a critical etiologic factor. In addition, time-keeping at the cellular level is affected as aging progresses, particularly in the adipocyte. In this Extra View we discuss the interactive role of three molecules, PPARγ, nocturnin and IGF-I in regulating stem cell fate in the marrow and the potential implications of this network for understanding cellular aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.