ArticleApplied and environmental microbiology2010
Comparison of the pathogenic potentials of environmental and clinical vibrio parahaemolyticus strains indicates a role for temperature regulation in virulence.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
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- Long-term analysis of Vibrio vulnificus and Vibrio parahaemolyticus virulence factors and their environmental associations in the Chesapeake Bay, Maryland, US.Journal of applied microbiology · 2025Article
- Draft genomes of twoMicrobiology resource announcements · 2025Article
- Temperature Influences Antimicrobial Resistance and Virulence ofPathogens (Basel, Switzerland) · 2025Article
- In Vitro Ferrophilic Responses ofMicroorganisms · 2025Article
- Epidemiological characteristics, virulence genes, and antimicrobial resistance analysis ofFrontiers in microbiology · 2025Article
- Antibiotic resistance trends amongApplied and environmental microbiology · 2024Article
- Presence of Zonula Occludens Toxin-Coding Genes amongMicroorganisms · 2024Article
- Genetic and Phenotypic Virulence Potential of Non-O1/Non-O139Microorganisms · 2023Article
- Prevalence and antimicrobial resistance of food safety related Vibrio species in inland saline water shrimp culture farms.International microbiology : the official journal of the Spanish Society for Microbiology · 2023Article
- Sewage Promotes Vibrio vulnificus Growth and Alters Gene Transcription in Vibrio vulnificus CMCP6.Microbiology spectrum · 2022Article
- Vibrio spp and other potential pathogenic bacteria associated to microfibers in the North-Western Mediterranean Sea.PloS one · 2022Article
- Coastal water bacteriophages infect various sets ofFrontiers in microbiology · 2022Article
- An Increase of Seawater Temperature Upregulates the Expression ofFrontiers in microbiology · 2022Article
- Characterization and Analysis of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) in Pandemic and Non-PandemicMicroorganisms · 2021Article
- Article
- Molecular Detection and Distribution of Six Medically ImportantFrontiers in microbiology · 2021Article
- Adaptations ofFrontiers in microbiology · 2021Review
- Genotypic Diversity and Pathogenic Potential of Clinical and EnvironmentalFrontiers in microbiology · 2021Article
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Authors and funding
4 authors.
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Abstract
Although the presence of pathogenic Vibrio spp. in estuarine environments of northern New England has been known for some time (C. H. Bartley and L. W. Slanetz, Appl. Microbiol. 21: 965-966, 1971, and K. R. O'Neil, S. H. Jones, and D. J. Grimes, FEMS Microbiol. Lett. 60:163-167, 1990), their virulence and the relative threat they may pose to human health has yet to be evaluated. In this study, the virulence potential of 33 Vibrio parahaemolyticus isolates collected from the Great Bay Estuary of New Hampshire was assessed in comparison to that of clinical strains. The environmental isolates lack thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH), which are encoded by tdh and trh, respectively. Though not hemolytic, they do possess putative virulence factors, such type III secretion system 1, and are highly cytotoxic to human gastrointestinal cells. The expression of known and putative virulence-associated traits, including hemolysin, protease, motility, biofilm formation, and cytotoxicity, by clinical reference isolates correlated with increased temperature from 28°C to 37°C. In contrast, the environmental isolates did not induce their putative virulence-associated traits in response to a temperature of 37°C. We further identified a significant correlation between hemolytic activity and growth phase among clinical strains, whereby hemolysin production decreases with increasing cell density. The introduction of a tdh::gfp promoter fusion into the environmental strains revealed that they regulate this virulence-associated gene appropriately in response to temperature, indicating that their existing regulatory mechanisms are primed to manage newly acquired virulence genes.
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