ArticleCardiovascular research2011
The role of vascular myoglobin in nitrite-mediated blood vessel relaxation.
Article in Cardiovascular research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Vascular nitric oxide resistance in type 2 diabetes.Cell death & disease · 2023Review
- The role of globins in cardiovascular physiology.Physiological reviews · 2022Review
- Article
- Lessons from the post-genomic era: Globin diversity beyond oxygen binding and transport.Redox biology · 2020Review
- Inorganic nitrate and nitrite supplementation fails to improve skeletal muscle mitochondrial efficiency in mice and humans.The American journal of clinical nutrition · 2020Article
- Nitric oxide signalling in cardiovascular health and disease.Nature reviews. Cardiology · 2018Review
- Erythrocytes and Vascular Function: Oxygen and Nitric Oxide.Frontiers in physiology · 2018Review
- Impact of mitochondrial nitrite reductase on hemodynamics and myocardial contractility.Scientific reports · 2017Article
- Nitric oxide release by deoxymyoglobin nitrite reduction during cardiac ischemia: A mathematical model.Microvascular research · 2017Article
- The role of red blood cell S-nitrosation in nitrite bioactivation and its modulation by leucine and glucose.Redox biology · 2016Article
- Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans.British journal of pharmacology · 2015Article
- NO-Rich Diet for Lifestyle-Related Diseases.Nutrients · 2015Review
- The evolution of nitric oxide signalling in vertebrate blood vessels.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Review
- Mechanisms of human erythrocytic bioactivation of nitrite.The Journal of biological chemistry · 2015Article
- Role of blood and vascular smooth muscle in the vasoactivity of nitrite.American journal of physiology. Heart and circulatory physiology · 2014Article
- Values of troponin T and myoglobin predictive of non-cardiac ischemia in rats.Iranian journal of basic medical sciences · 2014Article
- Mechanisms of nitrite bioactivation.Nitric oxide : biology and chemistry · 2014Review
- Role of nitrite in regulation of fetal cephalic circulation in sheep.The Journal of physiology · 2014Article
- Characterization of the mechanism and magnitude of cytoglobin-mediated nitrite reduction and nitric oxide generation under anaerobic conditions.The Journal of biological chemistry · 2012Article
- Erythrocyte storage increases rates of NO and nitrite scavenging: implications for transfusion-related toxicity.The Biochemical journal · 2012Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
aimsThis work investigates the role of myoglobin in mediating the vascular relaxation induced by nitrite. Nitrite, previously considered an inert by-product of nitric oxide metabolism, is now believed to play an important role in several areas of pharmacology and physiology. Myoglobin can act as a nitrite reductase in the heart, where it is plentiful, but it is present at a far lower level in vascular smooth muscle-indeed, its existence in the vessel wall is controversial. Haem proteins have been postulated to be important in nitrite-induced vasodilation, but the specific role of myoglobin is unknown. The current study was designed to confirm the presence of myoglobin in murine aortic tissue and to test the hypothesis that vascular wall myoglobin is important for nitrite-induced vasodilation. METHODS AND
resultsAortic rings from wild-type and myoglobin knockout mice were challenged with nitrite, before and after exposure to the haem-protein inhibitor carbon monoxide (CO). CO inhibited vasodilation in wild-type rings but not in myoglobin-deficient rings. Restitution of myoglobin using a genetically modified adenovirus both increased vasodilation to nitrite and reinstated the wild-type pattern of response to CO.
conclusionMyoglobin is present in the murine vasculature and contributes significantly to nitrite-induced vasodilation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.