ArticleMolecular biology and evolution2011
A Bayesian phylogenetic method to estimate unknown sequence ages.
Article in Molecular biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed.
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- An ancient genome of Streptococcus pyogenes from a pre-Columbian Bolivian mummy.Nature communications · 2026Article
- A phylogenetic contribution to understanding the panzootic spread of African swine fever: from the global to the local scale.Virus evolution · 2026Article
- Profile and evolution of antimicrobial resistance genes in Staphylococcus aureus whole genomes in Africa revealed by phylogeography and bioinformatics.Scientific reports · 2025Article
- A 75,000-y-old Scandinavian Arctic cave deposit reveals past faunal diversity and paleoenvironment.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Million Years of Mammoth Mitogenome Evolution.Molecular biology and evolution · 2025Article
- How does date-rounding affect phylodynamic inference for public health?PLoS computational biology · 2025Article
- Molecular Epidemiology and Clinical Aspects of Dermatophytosis in Guiyang, Southwest China (2017-2023): A Single-Institution Retrospective Study.Mycopathologia · 2025Article
- Mapping Transmission Dynamics and Drug Resistance Surveillance in the Cyprus HIV-1 Epidemic (2017-2021).Viruses · 2024Article
- Highly pathogenic avian influenza A(H5N1) virus infections on fur farms connected to mass mortalities of black-headed gulls, Finland, July to October 2023.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- High pathogenic avian influenza A(H5) viruses of clade 2.3.4.4b in Europe-Why trends of virus evolution are more difficult to predict.Virus evolution · 2024Article
- Inferring Human Immunodeficiency Virus 1 Proviral Integration Dates With Bayesian Inference.Molecular biology and evolution · 2023Article
- Estimating the Age of Poorly Dated Fossil Specimens and Deposits Using a Total-Evidence Approach and the Fossilized Birth-Death Process.Systematic biology · 2023Article
- Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas.Viruses · 2023Article
- Article
- Phylogenetic-based inference reveals distinct transmission dynamics of SARS-CoV-2 lineages Gamma and P.2 in Brazil.iScience · 2022Article
- Lack of evolutionary changes identified in SARS-CoV-2 for the re-emerging outbreak of COVID-19 in Beijing, China.Biosafety and health · 2022Article
- The epidemic of the multiresistant dermatophyteFrontiers in immunology · 2022Article
18 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
Heterochronous data sets comprise molecular sequences sampled at different points in time. If the temporal range of the sampled sequences is large relative to the rate of mutation, the sampling times can directly calibrate evolutionary rates to calendar time. Here, we extend this calibration process to provide a full probabilistic method that utilizes temporal information in heterochronous data sets to estimate sampling times (leaf-ages) for sequenced for which this information unavailable. Our method is similar to relaxing the constraints of the molecular clock on specific lineages within a phylogenetic tree. Using a combination of synthetic and empirical data sets, we demonstrate that the method estimates leaf-ages reliably and accurately. Potential applications of our approach include incorporating samples of uncertain or radiocarbon-infinite age into ancient DNA analyses, evaluating the temporal signal in a particular sequence or data set, and exploring the reliability of sequence ages that are somehow contentious.
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