ArticleAmerican journal of physiology. Lung cellular and molecular physiology2010
Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma.
Article in American journal of physiology. Lung cellular and molecular physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02975258 (Adiposity and Airway Inflammation in HIV-Associated Airway Disease), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adiposity and Airway Inflammation in HIV-Associated Airway Disease
Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Dimethylarginine dimethylaminohydrolase 1 protects PMParticle and fibre toxicology · 2022Article
- Asymmetric Dimethylarginine Protects Neurons from Oxygen Glucose Deprivation Insult by Modulating Connexin-36 Expression.Oxidative medicine and cellular longevity · 2022Article
- Review - Nutraceuticals Can Target Asthmatic Bronchoconstriction: NADPH Oxidase-Dependent Oxidative Stress, RhoA and Calcium Dynamics.Journal of asthma and allergy · 2021Review
- Ovalbumin-sensitized mice have altered airway inflammation to agriculture organic dust.Respiratory research · 2019Article
- Dimethylarginine dimethylaminohydrolase (DDAH) overexpression enhances wound repair in airway epithelial cells exposed to agricultural organic dust.Inhalation toxicology · 2018Article
- Positive correlation of airway resistance and serum asymmetric dimethylarginine (ADMA) in bronchial asthma patients lacking evidence for systemic inflammation.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2018Article
- Relationship of Oxidant and Antioxidant Markers to Asthma Severity in Egyptian Asthmatic Children.Open access Macedonian journal of medical sciences · 2017Article
- Positive correlation of airway resistance and serum asymmetric dimethylarginine level in COPD patients with systemic markers of low-grade inflammation.International journal of chronic obstructive pulmonary disease · 2017Article
- Asymmetric Dimethylarginine and Its Relation As a Biomarker in Nephrologic Diseases.Biomarker insights · 2016Review
- Ets homologous factor regulates pathways controlling response to injury in airway epithelial cells.Nucleic acids research · 2014Article
- Treatment with the C5a receptor/CD88 antagonist PMX205 reduces inflammation in a murine model of allergic asthma.International immunopharmacology · 2014Article
- Dimethylarginine dimethylaminohydrolase (DDAH) overexpression attenuates agricultural organic dust extract-induced inflammation.Journal of environmental immunology and toxicology · 2014Article
- Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury.American journal of respiratory cell and molecular biology · 2014Article
- Overexpression of dimethylarginine dimethylaminohydrolase 1 attenuates airway inflammation in a mouse model of asthma.PloS one · 2014Article
- The endothelial ADMA/NO pathway in hypoxia-related chronic respiratory diseases.BioMed research international · 2014Review
- Vitamin D treatment modulates organic dust-induced cellular and airway inflammatory consequences.Journal of biochemical and molecular toxicology · 2013Article
- Article
- Asymmetric dimethylarginine blocks nitric oxide-mediated alcohol-stimulated cilia beating.Mediators of inflammation · 2013Article
- Protein Arginine Methyltransferases (PRMTs): promising targets for the treatment of pulmonary disorders.International journal of molecular sciences · 2012Review
- The role of iNOS inhibitors on lung injury induced by gastrointestinal decontamination agents aspiration.Journal of molecular histology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Nitric oxide (NO), formed by nitric oxide synthase (NOS), is an important mediator of lung inflammation in allergic asthma. Asymmetric dimethylarginine (ADMA), a competitive endogenous inhibitor of NOS, is metabolized by the enzyme dimethylarginine dimethylaminohydrolase (DDAH). Elevated ADMA has been shown to affect lung function in mice, and by inhibiting NOS it alters NO and reactive oxygen species production in mouse lung epithelial cells. However, the effects of altered ADMA levels during lung inflammation have not been explored. A model of allergen-induced airway inflammation was utilized in combination with the modulation of endogenous circulating ADMA levels in mice. Airway inflammation was assessed by quantifying inflammatory cell infiltrates in lung lavage and by histology. Lung DDAH expression was assessed by quantitative PCR and immunohistochemistry. Nitrite levels were determined in lung lavage fluid as a measure of NO production. iNOS expression was determined by immunohistochemistry, immunofluorescence, Western blot, and quantitative PCR. NF-κB binding activity was assessed by a transcription factor binding assay. Allergen-induced lung inflammation was potentiated in mice with elevated circulating ADMA and was reduced in mice overexpressing DDAH. Elevated ADMA reduced nitrite levels in lung lavage fluid in both allergen-challenged and control animals. ADMA increased iNOS expression in airway epithelial cells in vivo following allergen challenge and in vitro in stimulated mouse lung epithelial cells. ADMA also increased NF-κB binding activity in airway epithelial cells in vitro. These data support that ADMA may play a role in inflammatory airway diseases such as asthma through modulation of iNOS expression in lung epithelial cells.
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