Trial reportThe Journal of pediatrics2011
Efficacy of succimer chelation of mercury at background exposures in toddlers: a randomized trial.
Trial report in The Journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Efficacy of N,N'bis-(2-mercaptoethyl) isophthalamide on mercury intoxication: a randomized controlled trial.Environmental health : a global access science source · 2018Trial
- The impact of succimer chelation on blood cadmium in children with background exposures: a randomized trial.The Journal of pediatrics · 2013Trial
- Mercury poisoning-associated membranous nephropathy and autoimmune encephalitis.BMC nephrology · 2025Article
- Clinical management of chronic mercury intoxication secondary to skin lightening products: A proposed algorithm.Bosnian journal of basic medical sciences · 2021Review
- The Role of Xenobiotics and Trace Metals in Parkinson's Disease.Molecular neurobiology · 2020Review
- The Foundation in Evidence of Medical and Dental Telephone Consultations.Deutsches Arzteblatt international · 2016Article
- Article
- Postnatal exposure to methyl mercury and neuropsychological development in 7-year-old urban inner-city children exposed to lead in the United States.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveTo examine whether succimer, a mercaptan compound known to reduce blood lead concentration in children, reduces blood mercury concentration. STUDY
designWe used samples from a randomized clinical trial of succimer chelation for lead-exposed children. We measured mercury levels in pre-treatment samples from 767 children. We also measured mercury levels in blood samples drawn 1 week after treatment began (n = 768) and in a 20% random sample of the children who received the maximum 3 courses of treatment (n = 67). A bootstrap-based isotonic regression method was used to compare the trend with time in the difference between the adjusted mean mercury concentrations in the succimer group and that in the placebo group.
resultsThe adjusted mean organic mercury concentration in the succimer group relative to the placebo group fell from 99% at baseline to 82% after 3 courses of treatment (P for trend = .048), but this resulted from the prevention of the age-related increase in the succimer group.
conclusionSuccimer chelation for low level organic mercury exposure in children has limited efficacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.